Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

Seungyoun Jung, Naomi Allen, Alan A. Arslan, Laura Baglietto, Louise A. Brinton, Brian L. Egleston, Roni Falk, Renée T. Fortner, Kathy J. Helzlsouer, Annika Idahl, Rudolph Kaaks, Eva Lundin, Melissa Merritt, Charlotte Onland-Moret, Sabina Rinaldi, María José Sánchez, Sabina Sieri, Helena Schock, Xiao Ou Shu, Patrick M. SlussPaul N. Staats, Ruth C. Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley Tworoger, Kala Visvanathan, Vittorio Krogh, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Wei Zheng, Joanne F. Dorgan

Research output: Contribution to journalArticle

Abstract

Objective To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. Design Cross-sectional study. Setting Not applicable. Patient(s) A total of 671 premenopausal women not known to have cancer. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. Result(s) Older women had significantly lower AMH concentrations (≥40 [n = 444] vs. <35 years [n = 64], multivariable-adjusted median 0.73 ng/mL vs. 2.52 ng/mL). Concentrations of AMH were also significantly lower among women with earlier age at menarche (<12 [n = 96] vs. ≥14 years [n = 200]: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n = 27) compared with never or former users (n = 468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity, and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). Conclusion(s) Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche, and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles.

Original languageEnglish (US)
Pages (from-to)1012-1022.e2
JournalFertility and Sterility
Volume107
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Antimüllerian hormone
  • demographic
  • lifestyle
  • ovarian reserve
  • reproductive factors

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Jung, S., Allen, N., Arslan, A. A., Baglietto, L., Brinton, L. A., Egleston, B. L., Falk, R., Fortner, R. T., Helzlsouer, K. J., Idahl, A., Kaaks, R., Lundin, E., Merritt, M., Onland-Moret, C., Rinaldi, S., Sánchez, M. J., Sieri, S., Schock, H., Shu, X. O., ... Dorgan, J. F. (2017). Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women. Fertility and Sterility, 107(4), 1012-1022.e2. https://doi.org/10.1016/j.fertnstert.2017.02.105