Demographic factors influence cognitive recovery after shunt for normal-pressure hydrocephalus

Shannon Chang, Sachin Agarwal, Michael A. Williams, Daniele Rigamonti, Argye Hillis-Trupe

Research output: Contribution to journalArticle

Abstract

Background: Several studies have reported that ventriculoperitoneal shunt insertion for treatment of normal-pressure hydrocephalus results in improvement of gait and, less frequently, improvement of cognition. We sought to identify the demographic factors associated with cognitive improvement after shunt insertion to improve assessment of prognosis for cognitive gains with treatment. Review Summary: We report cognitive testing before and after ventriculoperitoneal shunt insertion in 36 patients with normal pressure hydrocephalus, who previously had improvement of any clinical symptom - gait, urinary incontinence, cognition - after a diagnostic trial of continuous cerebrospinal fluid drainage. Conclusions: One third of patients met our definition of good cognitive improvement: improvement by at least 25% on at least half of the cognitive tests administered. There was a significant negative linear relationship between age and probability of good cognitive improvement. Additionally, the degree of cognitive improvement was found to be greater in women than men (P = 0.002). Age was found to be a better predictor of improvement on memory tests, while sex was a better predictor of improvement on non-memory tests after shunt insertion.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalNeurologist
Volume12
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Normal Pressure Hydrocephalus
Ventriculoperitoneal Shunt
Gait
Cognition
Demography
Urinary Incontinence
Therapeutics
Cerebrospinal Fluid Leak

Keywords

  • Neuropsychological testing
  • Normal-pressure hydrocephalus
  • Outcomes
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Demographic factors influence cognitive recovery after shunt for normal-pressure hydrocephalus. / Chang, Shannon; Agarwal, Sachin; Williams, Michael A.; Rigamonti, Daniele; Hillis-Trupe, Argye.

In: Neurologist, Vol. 12, No. 1, 01.2006, p. 39-42.

Research output: Contribution to journalArticle

Chang, Shannon ; Agarwal, Sachin ; Williams, Michael A. ; Rigamonti, Daniele ; Hillis-Trupe, Argye. / Demographic factors influence cognitive recovery after shunt for normal-pressure hydrocephalus. In: Neurologist. 2006 ; Vol. 12, No. 1. pp. 39-42.
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