Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: Baseline results from the sentinel site of the olestra post-marketing surveillance study

Cheryl L. Rock, Mark D. Thornquist, Alan R. Kristal, Ruth E. Patterson, Dale A. Cooper, Marian L. Neuhouser, Dianne Neumark-Sztainer, Lawrence J Cheskin

Research output: Contribution to journalArticle

Abstract

Biochemical measures of nutrients or other dietary constituents can be an important component of nutritional assessment and monitoring. However, accurate interpretation of the nutrient concentration is dependent on knowledge of the determinants of the body pool measured. The purpose of this study was to identify the determinants of serum carotenoid and fat-soluble vitamin concentrations in a large, community-based sample (n = 1042). Multiple linear regression analysis was used to examine effects of demographic characteristics (age, sex, race/ethnicity, education), health- related behavior (exercise, sun exposure, smoking, alcohol consumption), and intake (diet, supplements) on serum retinol, 25-hydroxyvitamin D, α- tocopherol, phylloquinone, and carotenoid concentrations. Age, sex, race/ethnicity, vitamin A intake, and alcohol consumption were found to be determinants of serum retinol concentration. Race/ethnicity, vitamin D intake, body mass index, smoking status, and sun exposure were determinants of serum 25-hydroxyvitamin D concentration. Determinants of serum α- tocopherol were age, sex, race/ethnicity, α-tocopherol intake, serum cholesterol, percentage of energy from fat (inversely related), supplement use, and body mass index. Age, sex, phylloquinone intake, serum triglycerides, and supplement use were determinants of serum phylloquinone concentration. Primary determinants of serum carotenoids were age, sex, race/ethnicity, carotenoid intake, serum cholesterol, alcohol consumption, body mass index, and smoking status. Overall, the demographic, dietary, and other lifestyle factors explained little of the variability in serum concentrations of retinol (R2 = 0.20), 25-hydroxyvitamin D (R2 = 0.24), and the carotenoids (R2 = 0.15-0.26); only modest amounts of the variability n serum phylloquinone concentration (R2 = 0.40); and more substantial amounts of the variability in serum α-tocopherol concentration (R2 = 0.62).

Original languageEnglish (US)
Pages (from-to)855-864
Number of pages10
JournalJournal of Nutrition
Volume129
Issue number4
StatePublished - 1999

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sucrose polyester
fat soluble vitamins
phylloquinone
Carotenoids
nationalities and ethnic groups
Marketing
Vitamins
lifestyle
marketing
Life Style
carotenoids
demographic statistics
tocopherols
Fats
Demography
vitamin A
smoking (food products)
monitoring
gender
body mass index

Keywords

  • α- Tocopherol
  • 25-Hydroxyvitamin D
  • Carotenoids
  • Humans
  • Phylloquinone
  • Retinol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins : Baseline results from the sentinel site of the olestra post-marketing surveillance study. / Rock, Cheryl L.; Thornquist, Mark D.; Kristal, Alan R.; Patterson, Ruth E.; Cooper, Dale A.; Neuhouser, Marian L.; Neumark-Sztainer, Dianne; Cheskin, Lawrence J.

In: Journal of Nutrition, Vol. 129, No. 4, 1999, p. 855-864.

Research output: Contribution to journalArticle

Rock, CL, Thornquist, MD, Kristal, AR, Patterson, RE, Cooper, DA, Neuhouser, ML, Neumark-Sztainer, D & Cheskin, LJ 1999, 'Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: Baseline results from the sentinel site of the olestra post-marketing surveillance study', Journal of Nutrition, vol. 129, no. 4, pp. 855-864.
Rock, Cheryl L. ; Thornquist, Mark D. ; Kristal, Alan R. ; Patterson, Ruth E. ; Cooper, Dale A. ; Neuhouser, Marian L. ; Neumark-Sztainer, Dianne ; Cheskin, Lawrence J. / Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins : Baseline results from the sentinel site of the olestra post-marketing surveillance study. In: Journal of Nutrition. 1999 ; Vol. 129, No. 4. pp. 855-864.
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abstract = "Biochemical measures of nutrients or other dietary constituents can be an important component of nutritional assessment and monitoring. However, accurate interpretation of the nutrient concentration is dependent on knowledge of the determinants of the body pool measured. The purpose of this study was to identify the determinants of serum carotenoid and fat-soluble vitamin concentrations in a large, community-based sample (n = 1042). Multiple linear regression analysis was used to examine effects of demographic characteristics (age, sex, race/ethnicity, education), health- related behavior (exercise, sun exposure, smoking, alcohol consumption), and intake (diet, supplements) on serum retinol, 25-hydroxyvitamin D, α- tocopherol, phylloquinone, and carotenoid concentrations. Age, sex, race/ethnicity, vitamin A intake, and alcohol consumption were found to be determinants of serum retinol concentration. Race/ethnicity, vitamin D intake, body mass index, smoking status, and sun exposure were determinants of serum 25-hydroxyvitamin D concentration. Determinants of serum α- tocopherol were age, sex, race/ethnicity, α-tocopherol intake, serum cholesterol, percentage of energy from fat (inversely related), supplement use, and body mass index. Age, sex, phylloquinone intake, serum triglycerides, and supplement use were determinants of serum phylloquinone concentration. Primary determinants of serum carotenoids were age, sex, race/ethnicity, carotenoid intake, serum cholesterol, alcohol consumption, body mass index, and smoking status. Overall, the demographic, dietary, and other lifestyle factors explained little of the variability in serum concentrations of retinol (R2 = 0.20), 25-hydroxyvitamin D (R2 = 0.24), and the carotenoids (R2 = 0.15-0.26); only modest amounts of the variability n serum phylloquinone concentration (R2 = 0.40); and more substantial amounts of the variability in serum α-tocopherol concentration (R2 = 0.62).",
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