TY - JOUR
T1 - Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India
AU - Chery, Laura
AU - Maki, Jennifer N.
AU - Mascarenhas, Anjali
AU - Walke, Jayashri T.
AU - Gawas, Pooja
AU - Almeida, Anvily
AU - Fernandes, Mezia
AU - Vaz, Marina
AU - Ramanan, Rakesh
AU - Shirodkar, Diksha
AU - Bernabeu, Maria
AU - Manoharan, Suresh Kumar
AU - Pereira, Ligia
AU - Dash, Rashmi
AU - Sharma, Ambika
AU - Shaik, Riaz Basha
AU - Chakrabarti, Rimi
AU - Babar, Prasad
AU - White, John
AU - Mudeppa, Devaraja G.
AU - Kumar, Shiva
AU - Zuo, Wenyun
AU - Skillman, Kristen M.
AU - Kanjee, Usheer
AU - Lim, Caeul
AU - Shaw-Saliba, Kathryn
AU - Kumar, Ashwani
AU - Valecha, Neena
AU - Jindal, V. N.
AU - Khandeparkar, Anar
AU - Naik, Pradeep
AU - Amonkar, Sunanda
AU - Duraisingh, Manoj T.
AU - Tuljapurkar, Shripad
AU - Smith, Joseph D.
AU - Dubhashi, Nagesh
AU - Pinto, Roque G.W.
AU - Silveria, Maria
AU - Gomes, Edwin
AU - Rathod, Pradipsinh K.
N1 - Funding Information:
This work was supported by the US NIAID MESA-ICEMR Program Project U19 AI089688 to PKR of the University of Washington, Seattle, WA, USA, and by the Government of India (Indian Council of Medical Research and the National Institute of Malaria Research).
PY - 2016/11/25
Y1 - 2016/11/25
N2 - Background: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. Methods: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P. falciparum and P. vivax infection on univariate analysis. Results: Between 2012 and 2015, 74,571 febrile individuals, 6287 (8.4%) of whom were malaria positive, presented to GMC. The total number of malaria cases at GMC increased more than two-fold over four years, with both P. vivax and P. falciparum cases present year-round. Some 1116 malaria-positive individuals (mean age = 27, 91% male), 88.2% of whom were born outside of Goa and 51% of whom were construction workers, were enroled in the study. Of 1088 confirmed malaria-positive patients, 77.0% had P. vivax, 21.0% had P. falciparum and 2.0% had mixed malaria. Patients over 40 years of age and with P. falciparum infection were significantly (p < 0.001) more likely to be hospitalised than younger and P. vivax patients, respectively. While approximately equal percentages of hospitalised P. falciparum (76.6%) and P. vivax (78.9%) cases presented with at least one WHO severity indicator, a greater percentage of P. falciparum inpatients presented with at least two (43.9%, p < 0.05) and at least three (29.9%, p < 0.01) severity features. There were six deaths among the 182 hospitalised malaria positive patients, all of whom had P. falciparum. Conclusion: During the four year study period at GMC, the number of malaria cases increased substantially and the greatest burden of severe disease was contributed by P. falciparum.
AB - Background: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. Methods: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P. falciparum and P. vivax infection on univariate analysis. Results: Between 2012 and 2015, 74,571 febrile individuals, 6287 (8.4%) of whom were malaria positive, presented to GMC. The total number of malaria cases at GMC increased more than two-fold over four years, with both P. vivax and P. falciparum cases present year-round. Some 1116 malaria-positive individuals (mean age = 27, 91% male), 88.2% of whom were born outside of Goa and 51% of whom were construction workers, were enroled in the study. Of 1088 confirmed malaria-positive patients, 77.0% had P. vivax, 21.0% had P. falciparum and 2.0% had mixed malaria. Patients over 40 years of age and with P. falciparum infection were significantly (p < 0.001) more likely to be hospitalised than younger and P. vivax patients, respectively. While approximately equal percentages of hospitalised P. falciparum (76.6%) and P. vivax (78.9%) cases presented with at least one WHO severity indicator, a greater percentage of P. falciparum inpatients presented with at least two (43.9%, p < 0.05) and at least three (29.9%, p < 0.01) severity features. There were six deaths among the 182 hospitalised malaria positive patients, all of whom had P. falciparum. Conclusion: During the four year study period at GMC, the number of malaria cases increased substantially and the greatest burden of severe disease was contributed by P. falciparum.
KW - Characteristics
KW - Diagnostics
KW - Epidemiology
KW - Features
KW - Goa
KW - MESA-ICEMR
KW - Severity
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U2 - 10.1186/s12936-016-1619-5
DO - 10.1186/s12936-016-1619-5
M3 - Article
C2 - 27884146
AN - SCOPUS:84996962818
VL - 15
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
IS - 1
M1 - 569
ER -