Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

Gill Livingston; Jonathan Huntley; Andrew Sommerlad; David Ames; Clive Ballard; Sube Banerjee; Carol Brayne; Alistair Burns; Jiska Cohen-Mansfield; Claudia Cooper; Sergi G. Costafreda; Amit Dias; Nick Fox; Laura N. Gitlin; Robert Howard; Helen C. Kales; Mika Kivimäki; Eric B. Larson; Adesola Ogunniyi; Vasiliki Orgeta; Karen Ritchie; Kenneth Rockwood; Elizabeth L. Sampson; Quincy Samus; Lon S. Schneider; Geir Selbæk; Linda Teri; Naaheed Mukadam

doi:10.1016/S0140-6736(20)30367-6

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

Gill Livingston, Jonathan Huntley, Andrew Sommerlad, David Ames, Clive Ballard, Sube Banerjee, Carol Brayne, Alistair Burns, Jiska Cohen-Mansfield, Claudia Cooper, Sergi G. Costafreda, Amit Dias, Nick Fox, Laura N. Gitlin, Robert Howard, Helen C. Kales, Mika Kivimäki, Eric B. Larson, Adesola Ogunniyi, Vasiliki OrgetaKaren Ritchie, Kenneth Rockwood, Elizabeth L. Sampson, Quincy Samus, Lon S. Schneider, Geir Selbæk, Linda Teri, Naaheed Mukadam

Research output: Contribution to journal › Review article › peer-review

Original language	English (US)
Pages (from-to)	413-446
Number of pages	34
Journal	The Lancet
Volume	396
Issue number	10248
DOIs	https://doi.org/10.1016/S0140-6736(20)30367-6
State	Published - Aug 8 2020

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/S0140-6736(20)30367-6

Cite this

Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., Costafreda, S. G., Dias, A., Fox, N., Gitlin, L. N., Howard, R., Kales, H. C., Kivimäki, M., Larson, E. B., Ogunniyi, A., ... Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396(10248), 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6

Dementia prevention, intervention, and care : 2020 report of the Lancet Commission. / Livingston, Gill; Huntley, Jonathan; Sommerlad, Andrew; Ames, David; Ballard, Clive; Banerjee, Sube; Brayne, Carol; Burns, Alistair; Cohen-Mansfield, Jiska; Cooper, Claudia; Costafreda, Sergi G.; Dias, Amit; Fox, Nick; Gitlin, Laura N.; Howard, Robert; Kales, Helen C.; Kivimäki, Mika; Larson, Eric B.; Ogunniyi, Adesola; Orgeta, Vasiliki; Ritchie, Karen; Rockwood, Kenneth; Sampson, Elizabeth L.; Samus, Quincy; Schneider, Lon S.; Selbæk, Geir; Teri, Linda; Mukadam, Naaheed.

In: The Lancet, Vol. 396, No. 10248, 08.08.2020, p. 413-446.

Research output: Contribution to journal › Review article › peer-review

Livingston, G, Huntley, J, Sommerlad, A, Ames, D, Ballard, C, Banerjee, S, Brayne, C, Burns, A, Cohen-Mansfield, J, Cooper, C, Costafreda, SG, Dias, A, Fox, N, Gitlin, LN, Howard, R, Kales, HC, Kivimäki, M, Larson, EB, Ogunniyi, A, Orgeta, V, Ritchie, K, Rockwood, K, Sampson, EL, Samus, Q, Schneider, LS, Selbæk, G, Teri, L & Mukadam, N 2020, 'Dementia prevention, intervention, and care: 2020 report of the Lancet Commission', The Lancet, vol. 396, no. 10248, pp. 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6

Livingston, Gill ; Huntley, Jonathan ; Sommerlad, Andrew ; Ames, David ; Ballard, Clive ; Banerjee, Sube ; Brayne, Carol ; Burns, Alistair ; Cohen-Mansfield, Jiska ; Cooper, Claudia ; Costafreda, Sergi G. ; Dias, Amit ; Fox, Nick ; Gitlin, Laura N. ; Howard, Robert ; Kales, Helen C. ; Kivimäki, Mika ; Larson, Eric B. ; Ogunniyi, Adesola ; Orgeta, Vasiliki ; Ritchie, Karen ; Rockwood, Kenneth ; Sampson, Elizabeth L. ; Samus, Quincy ; Schneider, Lon S. ; Selbæk, Geir ; Teri, Linda ; Mukadam, Naaheed. / Dementia prevention, intervention, and care : 2020 report of the Lancet Commission. In: The Lancet. 2020 ; Vol. 396, No. 10248. pp. 413-446.

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title = "Dementia prevention, intervention, and care: 2020 report of the Lancet Commission",

author = "Gill Livingston and Jonathan Huntley and Andrew Sommerlad and David Ames and Clive Ballard and Sube Banerjee and Carol Brayne and Alistair Burns and Jiska Cohen-Mansfield and Claudia Cooper and Costafreda, {Sergi G.} and Amit Dias and Nick Fox and Gitlin, {Laura N.} and Robert Howard and Kales, {Helen C.} and Mika Kivim{\"a}ki and Larson, {Eric B.} and Adesola Ogunniyi and Vasiliki Orgeta and Karen Ritchie and Kenneth Rockwood and Sampson, {Elizabeth L.} and Quincy Samus and Schneider, {Lon S.} and Geir Selb{\ae}k and Linda Teri and Naaheed Mukadam",

note = "Funding Information: AS reports grants from Wellcome Trust (200163/Z/15/Z), outside the submitted work. DA reports grants from Eli Lilly, during the conduct of the study. CBa reports grants and personal fees from Aca-dia and Lundbeck; and personal fees from Roche, Otsuka, Biogen, Eli Lilly, and Pfizer, outside the sub-mitted work. SB reports grants and personal fees from AbbVie, personal fees and non-financial sup-port from Eli Lilly, and personal fees from Eleusis, Daval International, Boehringer Ingelheim, Axovant Sciences, Lundbeck, and Nutricia, outside the submitted work; and he has been employed by the Department of Health for England. NF reports non-financial support from Eli Lilly, outside the submitted work. LNG and her institutions (Johns Hopkins University, Baltimore, MD, USA, Drexel University, Philadelphia, PA, USA, and Thomas Jefferson University, Philadelphia, PA, USA) are entitled to receive royalties from fees associated with online training for the tailored activity program, which is an evidence-based program referenced in the Review. RH reports grants from Department of Health, NIHR HTA Programme, outside the submitted work; and he is a Scientific Trustee of the charity Alzheimer's Research UK. MK reports grants from the UK Medical Research Council (S011676, R024227), NordForsk (the Nordic Programme on Health and Welfare, 75021) and the Academy of Finland (311492), outside the submitted work. EBL reports other (royalties) from UpToDate, outside the submitted work. KRo reports personal fees from Clinical Cardio Day-Cape Breton University, Sydney, NS, Canada, CRUIGM-Montreal, Jackson Laboratory, Bar Harbor, MA, USA (speaker fees), MouseAge, Rome, Italy (speaker fees), Lundbeck, Frontemporal Dementia Study-Group, SunLife Insurance, Japan, outside the submitted work. He is a President and Chief Science Officer of DGI Clinical, which in the last 5 years has contracts with pharma and device manufacturers (Baxter, Baxalta, Shire, Hollister, Nutricia, Roche, Otsuka) on individualised outcome measurement. In 2017, he attended an advisory board meeting with Lundbeck. He is also Associate Director of the Canadian Consortium on Neurodegeneration in Aging, which is funded by the Canadian Institutes of Health Research, and with additional funding from the Alzheimer Society of Canada and several other charities, as well as, in its first phase (2013-2018), from Pfizer Canada and Sanofi Canada. He receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the QEII Health Science Centre Foundation, the Capital Health Research Fund and the Fountain Family Innovation Fund of the QEII Health Science Centre Foundation. LSS reports grants and personal fees from Eli Lilly, Merck, and Roche/Genentech; personal fees from Avraham, Boehringer Ingelheim, Neurim, Neuronix, Cognition, Eisai, Takeda, vTv, and Abbott; and grants from Biogen, Novartis, Biohaven, and Washington University DIAN-TU, outside the submitted work. The remaining authors declare no conflict of interests. Funding Information: We are partnered by University College London (UCL), the Alzheimer's Society, UK, the Economic and Social Research Council, and Alzheimer's Research UK, and would like to thank them for financial help. These organisations funded the fares, accommodation, and food for the Commission meeting but had no role in the writing of the manuscript or the decision to submit it for publication. We would like to thank Bernadette Courtney, Jacques Gianino, and Nuj Monowari, from UCL, London, UK, for their administrative help, including managing finances, booking rooms and food, and setting up a website supported by the University College London Hospitals National Institute for Health Research Biomedical Research Centre. We would like thank Henrik Zetterberg for advice on biomarkers and dementia. ",

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AU - Livingston, Gill

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AU - Sommerlad, Andrew

AU - Ames, David

AU - Ballard, Clive

AU - Banerjee, Sube

AU - Brayne, Carol

AU - Burns, Alistair

AU - Cohen-Mansfield, Jiska

AU - Cooper, Claudia

AU - Costafreda, Sergi G.

AU - Dias, Amit

AU - Fox, Nick

AU - Gitlin, Laura N.

AU - Howard, Robert

AU - Kales, Helen C.

AU - Kivimäki, Mika

AU - Larson, Eric B.

AU - Ogunniyi, Adesola

AU - Orgeta, Vasiliki

AU - Ritchie, Karen

AU - Rockwood, Kenneth

AU - Sampson, Elizabeth L.

AU - Samus, Quincy

AU - Schneider, Lon S.

AU - Selbæk, Geir

AU - Teri, Linda

AU - Mukadam, Naaheed

N1 - Funding Information: AS reports grants from Wellcome Trust (200163/Z/15/Z), outside the submitted work. DA reports grants from Eli Lilly, during the conduct of the study. CBa reports grants and personal fees from Aca-dia and Lundbeck; and personal fees from Roche, Otsuka, Biogen, Eli Lilly, and Pfizer, outside the sub-mitted work. SB reports grants and personal fees from AbbVie, personal fees and non-financial sup-port from Eli Lilly, and personal fees from Eleusis, Daval International, Boehringer Ingelheim, Axovant Sciences, Lundbeck, and Nutricia, outside the submitted work; and he has been employed by the Department of Health for England. NF reports non-financial support from Eli Lilly, outside the submitted work. LNG and her institutions (Johns Hopkins University, Baltimore, MD, USA, Drexel University, Philadelphia, PA, USA, and Thomas Jefferson University, Philadelphia, PA, USA) are entitled to receive royalties from fees associated with online training for the tailored activity program, which is an evidence-based program referenced in the Review. RH reports grants from Department of Health, NIHR HTA Programme, outside the submitted work; and he is a Scientific Trustee of the charity Alzheimer's Research UK. MK reports grants from the UK Medical Research Council (S011676, R024227), NordForsk (the Nordic Programme on Health and Welfare, 75021) and the Academy of Finland (311492), outside the submitted work. EBL reports other (royalties) from UpToDate, outside the submitted work. KRo reports personal fees from Clinical Cardio Day-Cape Breton University, Sydney, NS, Canada, CRUIGM-Montreal, Jackson Laboratory, Bar Harbor, MA, USA (speaker fees), MouseAge, Rome, Italy (speaker fees), Lundbeck, Frontemporal Dementia Study-Group, SunLife Insurance, Japan, outside the submitted work. He is a President and Chief Science Officer of DGI Clinical, which in the last 5 years has contracts with pharma and device manufacturers (Baxter, Baxalta, Shire, Hollister, Nutricia, Roche, Otsuka) on individualised outcome measurement. In 2017, he attended an advisory board meeting with Lundbeck. He is also Associate Director of the Canadian Consortium on Neurodegeneration in Aging, which is funded by the Canadian Institutes of Health Research, and with additional funding from the Alzheimer Society of Canada and several other charities, as well as, in its first phase (2013-2018), from Pfizer Canada and Sanofi Canada. He receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research, and research support from the Canadian Institutes of Health Research, the QEII Health Science Centre Foundation, the Capital Health Research Fund and the Fountain Family Innovation Fund of the QEII Health Science Centre Foundation. LSS reports grants and personal fees from Eli Lilly, Merck, and Roche/Genentech; personal fees from Avraham, Boehringer Ingelheim, Neurim, Neuronix, Cognition, Eisai, Takeda, vTv, and Abbott; and grants from Biogen, Novartis, Biohaven, and Washington University DIAN-TU, outside the submitted work. The remaining authors declare no conflict of interests. Funding Information: We are partnered by University College London (UCL), the Alzheimer's Society, UK, the Economic and Social Research Council, and Alzheimer's Research UK, and would like to thank them for financial help. These organisations funded the fares, accommodation, and food for the Commission meeting but had no role in the writing of the manuscript or the decision to submit it for publication. We would like to thank Bernadette Courtney, Jacques Gianino, and Nuj Monowari, from UCL, London, UK, for their administrative help, including managing finances, booking rooms and food, and setting up a website supported by the University College London Hospitals National Institute for Health Research Biomedical Research Centre. We would like thank Henrik Zetterberg for advice on biomarkers and dementia.

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