Delta-positive t-cell lymphoma that produces interferon gamma

To the Editor: The clinicopathologic features of the patient described by Burg et al. (Oct. 10 issue)¹ who had a subcutaneous T-cell lymphoma simulating panniculitis are similar to those of a series of eight patients we recently described.² A notable feature of subcutaneous T-cell lymphoma is its association with a hemophagocytic syndrome, which was the case in six of the patients we described.² Although this complication was not described in the patient of Burg et al.,¹ the clinical findings of fever and leukopenia suggest this possibility. The apparent production of interferon gamma by the neoplastic cells could be a pathogenetic.