Delta-positive t-cell lymphoma that produces interferon gamma

Christopher L. Gonzalez, L. Jeffrey Medeiros, Elaine S. Jaffe, Günter Burg, Reinhard Dummer, Martin Wilhelm, Frank Nestle, Maria Michaela Ott, Alfred Feller, Hiltrud Hefner, Ute Lanz, Andreas Schwinn

Research output: Contribution to journalLetterpeer-review


To the Editor: The clinicopathologic features of the patient described by Burg et al. (Oct. 10 issue)1 who had a subcutaneous T-cell lymphoma simulating panniculitis are similar to those of a series of eight patients we recently described.2 A notable feature of subcutaneous T-cell lymphoma is its association with a hemophagocytic syndrome, which was the case in six of the patients we described.2 Although this complication was not described in the patient of Burg et al.,1 the clinical findings of fever and leukopenia suggest this possibility. The apparent production of interferon gamma by the neoplastic cells could be a pathogenetic.

Original languageEnglish (US)
Pages (from-to)1088-1089
Number of pages2
JournalNew England Journal of Medicine
Issue number16
StatePublished - Apr 16 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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