Delivery of local therapeutics to the brain: Working toward advancing treatment for malignant gliomas

Kaisorn L. Chaichana, Leon Pinheiro, Henry Brem

Research output: Contribution to journalReview articlepeer-review

Abstract

Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.

Original languageEnglish (US)
Pages (from-to)353-369
Number of pages17
JournalTherapeutic Delivery
Volume6
Issue number3
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Pharmaceutical Science

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