Delipidated retroviruses as potential autologous therapeutic vaccines - A pilot experiment

Moiz Kltabwalla; Aftab A. Ansari; Francois Vlllinger; Hassibullah Akeefe; Adam P. Conner; Ann E. Mayne; James E K Hildreth

doi:10.3181/0712-RM-349

Delipidated retroviruses as potential autologous therapeutic vaccines - A pilot experiment

Moiz Kltabwalla, Aftab A. Ansari, Francois Vlllinger, Hassibullah Akeefe, Adam P. Conner, Ann E. Mayne, James E K Hildreth

Research output: Contribution to journal › Article › peer-review

Abstract

This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1,1 and 10 ig of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

Original language	English (US)
Pages (from-to)	732-740
Number of pages	9
Journal	Experimental Biology and Medicine
Volume	233
Issue number	6
DOIs	https://doi.org/10.3181/0712-RM-349
State	Published - Jun 2008
Externally published	Yes

Keywords

Delipidation
SIV
Therapeutic vaccination

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3181/0712-RM-349

Cite this

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abstract = "This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1,1 and 10 ig of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.",

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AU - Kltabwalla, Moiz

AU - Ansari, Aftab A.

AU - Vlllinger, Francois

AU - Akeefe, Hassibullah

AU - Conner, Adam P.

AU - Mayne, Ann E.

AU - Hildreth, James E K

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AB - This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1,1 and 10 ig of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

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Delipidated retroviruses as potential autologous therapeutic vaccines - A pilot experiment

Abstract

Keywords

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