In an individual homozygous for G(γ)-δβ-thalassemia, a physical alteration in γ-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A(γ)-globin chains resulted from extension of the DNA deletion from the δβ-globin gene region into the γ-globin gene region rather than a functional disturbance of γ-gene expression.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Clinical Investigation|
|State||Published - 1979|
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