Deletion of the Aγ-globin gene in Gγ-δβ-thalassemia

S. H. Orkin, B. P. Alter, C. Altay

Research output: Contribution to journalArticlepeer-review

Abstract

In an individual homozygous for G(γ)-δβ-thalassemia, a physical alteration in γ-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A(γ)-globin chains resulted from extension of the DNA deletion from the δβ-globin gene region into the γ-globin gene region rather than a functional disturbance of γ-gene expression.

Original languageEnglish (US)
Pages (from-to)866-869
Number of pages4
JournalJournal of Clinical Investigation
Volume64
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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