Deletion of the Aγ-globin gene in Gγ-δβ-thalassemia

In an individual homozygous for G(γ)-δβ-thalassemia, a physical alteration in γ-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A(γ)-globin chains resulted from extension of the DNA deletion from the δβ-globin gene region into the γ-globin gene region rather than a functional disturbance of γ-gene expression.