Deletion of Mycobacterium tuberculosis Sigma Factor E Results in Delayed Time to Death with Bacterial Persistence in the Lungs of Aerosol-Infected Mice

Masaru Ando, Tetsuyuki Yoshimatsu, Chiew Ko, Paul J. Converse, William R. Bishai

Research output: Contribution to journalArticle

Abstract

The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.

Original languageEnglish (US)
Pages (from-to)7170-7172
Number of pages3
JournalInfection and immunity
Volume71
Issue number12
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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