Deletion of β-catenin impairs T cell development

Youyuan Xu, Daliya Banerjee, Joerg Huelsken, Walter Birchmeier, Jyoti Misra Sen

Research output: Contribution to journalArticlepeer-review

Abstract

T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the αβ TCR. Here we show that T cell-specific deletion of β-catenin impaired T cell development at the β-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, β-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that β-catenin-mediated signals are required for normal T cell development.

Original languageEnglish (US)
Pages (from-to)1177-1182
Number of pages6
JournalNature Immunology
Volume4
Issue number12
DOIs
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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