Abstract
T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the αβ TCR. Here we show that T cell-specific deletion of β-catenin impaired T cell development at the β-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, β-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that β-catenin-mediated signals are required for normal T cell development.
Original language | English (US) |
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Pages (from-to) | 1177-1182 |
Number of pages | 6 |
Journal | Nature Immunology |
Volume | 4 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology