Deletion mapping of the regions with AMELY from two Chinese males

Jianhui Xie, Chengchen Shao, Hongmei Xu, Wei Zhu, Zhiping Liu, Qiqun Tang, Yueqin Zhou

Research output: Contribution to journalArticle

Abstract

The amelogenin (AMEL) is widely used in many multiplex PCR kits for gender determination. However, the null of amelogenin Y (AMELY) can result in the incorrect genotyping of male samples as females. In this study, we report the deletion of AMELY in two cases with a deletion frequency of 0.019% (2/10526) in our laboratory. The deletion region with AMELY was mapped by using other twelve loci, which shows the class I deletion pattern. Further, the Y chromosome short tandem repeat (Y-STR) typing shows that these two cases share the same haplotype with other two cases from previous reports. The haplogroup of the two cases was predicted as O3 haplogroup with a 100% probability. Altogether, this study will provide evidence to further demonstrate the deletion of AMELY in Chinese population.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalLegal Medicine
Volume16
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Keywords

  • AMEL
  • Chinese population
  • Deletion
  • DYS458
  • Haplogroup

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects
  • Medicine(all)

Cite this

Xie, J., Shao, C., Xu, H., Zhu, W., Liu, Z., Tang, Q., & Zhou, Y. (2014). Deletion mapping of the regions with AMELY from two Chinese males. Legal Medicine, 16(5), 290-292. https://doi.org/10.1016/j.legalmed.2014.05.002