Deletion mapping of polymorphic loci by apparent parental exclusion

S. P. Daiger, A. Chakravarti

Research output: Contribution to journalArticlepeer-review

Abstract

Depletion of a chromosome region containing a polymorphic marker may result in apparent parental exclusion at that locus. The authors present a general method for calculating the probability that deletion at a specific locus would have such an effect. For many autosomal loci this probability is substantial, justifying attempts at deletion mapping in most cases. This method may be especially valuable in assigning DNA restriction fragment polymorphisms to chromosome regions.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalAmerican journal of medical genetics
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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