Delays and barriers to early treatment initiation for childhood tuberculosis in India

C. Valvi, A. Chandanwale, S. Khadse, R. Kulkarni, D. Kadam, A. Kinikar, S. Joshi, R. Lokhande, G. Pardeshi, P. Garg, N. Gupte, D. Jain, N. Suryavanshi, J. E. Golub, A. Shankar, A. Gupta, G. Dhumal, A. Deluca, R. C. Bollinger

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: India accounts for 27% of global childhood tuberculosis (TB) burden. Understanding barriers to early diagnosis and treatment in children may improve care and outcomes. METHODS: A cross-sectional study was performed among 89 children initiated on anti-TB treatment from a public hospital in Pune during 2016, using a structured questionnaire and hospital records. Health care providers (HCPs) were defined as medical personnel consulted about the child’s TB symptoms. Time-to-treatment initiation (TTI) was defined as the number of days between onset of TB symptoms and anti-TB treatment initiation. Based on Revised National TB Control Programme recommendations, delayed TTI was defined as .28 days. RESULTS: Sixty-seven (75%) of 89 enrolled children had significant TTI delays (median 51 days, interquartile range [IQR] 27–86). Sixty-six (74%) children visited 1–8 HCPs in the private sector before approaching the public sector. The median HCP delay was 28 days (IQR 10–75). Bacille Calmette-Guérin vaccination (aOR 10.96, P ¼ 0.04) and loss of appetite (aOR 4.44, P ¼ 0.04) were associated with delayed TTI. CONCLUSION: The majority of the children had TTI delays due to delays by HCPs in the private sector. Strengthening HCP competency in TB symptom screening and encouraging early referrals are crucial for rapid scaling up of early treatment initiation in childhood TB.

Original languageEnglish (US)
Pages (from-to)1090-1099
Number of pages10
JournalInternational Journal of Tuberculosis and Lung Disease
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2019

Keywords

  • Health care provider delay
  • Health care system delay
  • Patient delay
  • Pediatric tuberculosis
  • TB diagnosis
  • TB treatment barriers

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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