Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

Arthur M. Dannenberg

doi:10.1016/0167-5699(91)90035-R

Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

Arthur M. Dannenberg

Research output: Contribution to journal › Review article › peer-review

226 Scopus citations

Abstract

It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

Original language	English (US)
Pages (from-to)	228-233
Number of pages	6
Journal	Immunology Today
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/0167-5699(91)90035-R
State	Published - Jul 1991
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(91)90035-R

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title = "Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis",

abstract = "It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.",

author = "Dannenberg, {Arthur M.}",

note = "Funding Information: The author appreciates the superb editorial assistance of Ilse M. Harrop, and the financial support of the Johns Hopkins Environmental Health Sciences Center Grant ES-03819, from the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina and grant HL-10342 from National Heart, Lung and Blood Institute, Bethesda, Maryland.",

year = "1991",

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N2 - It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

AB - It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

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Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

Abstract

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