Abstract
Objective: To determine whether simultaneous and/or delayed administration of sodium thiosulphate (STS) affects the oncologic effect of cisplatin or cisdiaminedichloroplatinum (CDDP) in EMT6 tumour cells in vitro. Setting: Cell biology research laboratory. Methods: Clonogenic assays of EMT6 tumour cells with CDDP alone, CDDP plus simultaneous STS, and CDDP plus a 4-hour delay of STS were performed. Growth fractions under these three conditions were compared. Results: Tumour growth was statistically significantly increased when CDDP and STS were administered compared with CDDP alone. There was no statistically significant difference between simultaneous and 4-hour delay of STS administration. We conclude that in EMT6 cells, either simultaneous administration or a 4-hour delay of STS administration significantly decreases CDDP efficacy. Conclusion: STS adversely affects CDDP's oncologic efficacy in EMT6 cell cultures in vitro.
Original language | English (US) |
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Pages (from-to) | 638-641 |
Number of pages | 4 |
Journal | Journal of Otolaryngology - Head and Neck Surgery |
Volume | 37 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2008 |
Keywords
- Cancer
- Chemotherapy
- Cisplatin
- Hair cell
- Hearing
- Ototoxicity
- Sodium thiosulphate
ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology