Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)

H. S. Darusman, J. Call, D. Sajuthi, S. J. Schapiro, A. Gjedde, O. Kalliokoski, J. Hau

Research output: Contribution to journalArticlepeer-review

Abstract

We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuo-spatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalPrimates
Volume55
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Aging
  • Neurodegenerative disease
  • Non-human primate
  • Working memory

ASJC Scopus subject areas

  • Animal Science and Zoology

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