Delayed recognition of human immunodeficiency virus infection in preadolescent children

Deborah Persaud, S. Chandwani, M. Rigaud, E. Leibovitz, A. Kaul, R. Lawrence, H. Pollack, D. DiJohn, K. Krasinski, W. Borkowsky

Research output: Contribution to journalArticle

Abstract

Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); Pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 genital wart, 1 chronic zoster); weight loss (3); malignancy (1); and nephropathy (1). Eight children were referred for evaluation because of maternal HIV-1 infection. The risk factors for HIV-1 infection included maternal/perinatal exposure (22), perinatal blood transfusion (6), blood transfusion during infancy (2), and sexual abuse (2). Ten (31%) of the 32 children have subsequently died. The longest survival from perinatal infection was 12 years. HIV-1 infection in children can result in a prolonged clinical latency and can masquerade as other pathologic conditions. The absence of clinical symptoms in older children at risk for HIV-1 infection should not deter HIV testing.

Original languageEnglish (US)
Pages (from-to)688-691
Number of pages4
JournalPediatrics
Volume90
Issue number5 I
StatePublished - 1992
Externally publishedYes

Fingerprint

Virus Diseases
HIV-1
HIV
Blood Transfusion
Maternal Exposure
Condylomata Acuminata
Pneumocystis Pneumonia
Idiopathic Thrombocytopenic Purpura
Sex Offenses
Herpes Zoster
Neutropenia
Bacterial Infections
Anemia
Weight Loss
Mothers
Skin
Infection
Neoplasms

Keywords

  • acquired immunodeficiency syndrome
  • human immunodeficiency virus
  • preadolescents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Persaud, D., Chandwani, S., Rigaud, M., Leibovitz, E., Kaul, A., Lawrence, R., ... Borkowsky, W. (1992). Delayed recognition of human immunodeficiency virus infection in preadolescent children. Pediatrics, 90(5 I), 688-691.

Delayed recognition of human immunodeficiency virus infection in preadolescent children. / Persaud, Deborah; Chandwani, S.; Rigaud, M.; Leibovitz, E.; Kaul, A.; Lawrence, R.; Pollack, H.; DiJohn, D.; Krasinski, K.; Borkowsky, W.

In: Pediatrics, Vol. 90, No. 5 I, 1992, p. 688-691.

Research output: Contribution to journalArticle

Persaud, D, Chandwani, S, Rigaud, M, Leibovitz, E, Kaul, A, Lawrence, R, Pollack, H, DiJohn, D, Krasinski, K & Borkowsky, W 1992, 'Delayed recognition of human immunodeficiency virus infection in preadolescent children', Pediatrics, vol. 90, no. 5 I, pp. 688-691.
Persaud D, Chandwani S, Rigaud M, Leibovitz E, Kaul A, Lawrence R et al. Delayed recognition of human immunodeficiency virus infection in preadolescent children. Pediatrics. 1992;90(5 I):688-691.
Persaud, Deborah ; Chandwani, S. ; Rigaud, M. ; Leibovitz, E. ; Kaul, A. ; Lawrence, R. ; Pollack, H. ; DiJohn, D. ; Krasinski, K. ; Borkowsky, W. / Delayed recognition of human immunodeficiency virus infection in preadolescent children. In: Pediatrics. 1992 ; Vol. 90, No. 5 I. pp. 688-691.
@article{a48dd10af3a848e0987ff3853f7d9b04,
title = "Delayed recognition of human immunodeficiency virus infection in preadolescent children",
abstract = "Thirty-two (18{\%}) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); Pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 genital wart, 1 chronic zoster); weight loss (3); malignancy (1); and nephropathy (1). Eight children were referred for evaluation because of maternal HIV-1 infection. The risk factors for HIV-1 infection included maternal/perinatal exposure (22), perinatal blood transfusion (6), blood transfusion during infancy (2), and sexual abuse (2). Ten (31{\%}) of the 32 children have subsequently died. The longest survival from perinatal infection was 12 years. HIV-1 infection in children can result in a prolonged clinical latency and can masquerade as other pathologic conditions. The absence of clinical symptoms in older children at risk for HIV-1 infection should not deter HIV testing.",
keywords = "acquired immunodeficiency syndrome, human immunodeficiency virus, preadolescents",
author = "Deborah Persaud and S. Chandwani and M. Rigaud and E. Leibovitz and A. Kaul and R. Lawrence and H. Pollack and D. DiJohn and K. Krasinski and W. Borkowsky",
year = "1992",
language = "English (US)",
volume = "90",
pages = "688--691",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "5 I",

}

TY - JOUR

T1 - Delayed recognition of human immunodeficiency virus infection in preadolescent children

AU - Persaud, Deborah

AU - Chandwani, S.

AU - Rigaud, M.

AU - Leibovitz, E.

AU - Kaul, A.

AU - Lawrence, R.

AU - Pollack, H.

AU - DiJohn, D.

AU - Krasinski, K.

AU - Borkowsky, W.

PY - 1992

Y1 - 1992

N2 - Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); Pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 genital wart, 1 chronic zoster); weight loss (3); malignancy (1); and nephropathy (1). Eight children were referred for evaluation because of maternal HIV-1 infection. The risk factors for HIV-1 infection included maternal/perinatal exposure (22), perinatal blood transfusion (6), blood transfusion during infancy (2), and sexual abuse (2). Ten (31%) of the 32 children have subsequently died. The longest survival from perinatal infection was 12 years. HIV-1 infection in children can result in a prolonged clinical latency and can masquerade as other pathologic conditions. The absence of clinical symptoms in older children at risk for HIV-1 infection should not deter HIV testing.

AB - Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); Pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 genital wart, 1 chronic zoster); weight loss (3); malignancy (1); and nephropathy (1). Eight children were referred for evaluation because of maternal HIV-1 infection. The risk factors for HIV-1 infection included maternal/perinatal exposure (22), perinatal blood transfusion (6), blood transfusion during infancy (2), and sexual abuse (2). Ten (31%) of the 32 children have subsequently died. The longest survival from perinatal infection was 12 years. HIV-1 infection in children can result in a prolonged clinical latency and can masquerade as other pathologic conditions. The absence of clinical symptoms in older children at risk for HIV-1 infection should not deter HIV testing.

KW - acquired immunodeficiency syndrome

KW - human immunodeficiency virus

KW - preadolescents

UR - http://www.scopus.com/inward/record.url?scp=0027071913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027071913&partnerID=8YFLogxK

M3 - Article

VL - 90

SP - 688

EP - 691

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 5 I

ER -