Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty

Massoud A. Leesar, Marcus F. Stoddard, Buddhadeb Dawn, Venu G. Jasti, Ronald Masden, Roberto Bolli

Research output: Contribution to journalArticle

Abstract

Background - Experimental studies suggest that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked pharmacologically. However, to date, no drug has been tested with respect to its ability to elicit a late PC effect in humans. As a consequence, clinical exploitation of the powerful anti-stunning and anti-infarct actions of late PC has been elusive thus far. Methods and Results - A total of 66 patients were randomized to receive a 4-hour intravenous infusion of nitroglycerin (NTG) or normal saline; on the following day, they underwent percutaneous transluminal coronary angioplasty (three 2-minute balloon inflations 5 minutes apart). Measurements of ST-segment shifts (intracoronary and surface ECGs), regional wall motion (quantitative 2D echocardiography), and chest pain score indicated that the infusion of NTG 24 hours before angioplasty rendered the myocardium relatively resistant to ischemia and that the degree of this cardioprotective effect was comparable to that afforded by the ischemia associated with the first balloon inflation in control subjects (early phase of ischemic PC). Collateral flow (estimated from a pressure-derived index) did not differ between control and NTG-pretreated patients, indicating that the enhanced tolerance to ischemia in NTG-pretreated patients cannot be accounted for by baseline differences in collateral function. Conclusions - NTG protects human myocardium against ischemia 24 hours after its administration. To the best of our knowledge, this is the first report that a late PC effect can be recruited pharmacologically in humans. The results suggest that prophylactic administration of nitrates could be a novel approach to the protection of the ischemic myocardium in patients.

Original languageEnglish (US)
Pages (from-to)2935-2941
Number of pages7
JournalCirculation
Volume103
Issue number24
DOIs
StatePublished - Jun 19 2001

Keywords

  • Collateral circulation
  • Ischemia
  • Myocardial infarction
  • Nitrates
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty'. Together they form a unique fingerprint.

  • Cite this

    Leesar, M. A., Stoddard, M. F., Dawn, B., Jasti, V. G., Masden, R., & Bolli, R. (2001). Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty. Circulation, 103(24), 2935-2941. https://doi.org/10.1161/01.CIR.103.24.2935