Delayed hemolytic transfusion reaction presenting as sickle-cell crisis

W. J. Diamond, F. L. Brown, P. Bitterman, H. G. Klein, R. J. Davey, R. M. Winslow

Research output: Contribution to journalArticle

Abstract

Eighteen patients with sickle-cell disease underwent partial exchange transfusion. Three developed delayed hemolytic reactions, with selective disappearance of transfused cells. All reactions occurred within 6 days of transfusion, and patients presented with the clinical features of painful crises. The two most severe reactions were associated with antibodies to Jk(a). These patients developed fever, arthritis, and a clinical course suggesting serum sickness. In both patients, other alloantibodies had previously been seen. A fourth patient developed multiple alloantibodies, accelerated destruction of transfused cells, but milder illness. Such reactions may be commoner than is appreciated and should be suspected when patients have recurrent or severe sickle crises after transfusion. Blood that is nonimmunogenic in antigen systems frequently associated with delayed hemolytic reactions (Rh, Kell, Duffy, and Kidd) is preferred for sickle-cell patients who lack these antigens, especially if these patients have previously demonstrated capability to form erythrocyte alloantibodies.

Original languageEnglish (US)
Pages (from-to)231
Number of pages1
JournalAnnals of Internal Medicine
Volume93
Issue number2
StatePublished - 1980
Externally publishedYes

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Isoantibodies
Serum Sickness
Antigens
Transfusion Reaction
Sickle Cell Anemia
Arthritis
Fever
Erythrocytes
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diamond, W. J., Brown, F. L., Bitterman, P., Klein, H. G., Davey, R. J., & Winslow, R. M. (1980). Delayed hemolytic transfusion reaction presenting as sickle-cell crisis. Annals of Internal Medicine, 93(2), 231.

Delayed hemolytic transfusion reaction presenting as sickle-cell crisis. / Diamond, W. J.; Brown, F. L.; Bitterman, P.; Klein, H. G.; Davey, R. J.; Winslow, R. M.

In: Annals of Internal Medicine, Vol. 93, No. 2, 1980, p. 231.

Research output: Contribution to journalArticle

Diamond, WJ, Brown, FL, Bitterman, P, Klein, HG, Davey, RJ & Winslow, RM 1980, 'Delayed hemolytic transfusion reaction presenting as sickle-cell crisis', Annals of Internal Medicine, vol. 93, no. 2, pp. 231.
Diamond WJ, Brown FL, Bitterman P, Klein HG, Davey RJ, Winslow RM. Delayed hemolytic transfusion reaction presenting as sickle-cell crisis. Annals of Internal Medicine. 1980;93(2):231.
Diamond, W. J. ; Brown, F. L. ; Bitterman, P. ; Klein, H. G. ; Davey, R. J. ; Winslow, R. M. / Delayed hemolytic transfusion reaction presenting as sickle-cell crisis. In: Annals of Internal Medicine. 1980 ; Vol. 93, No. 2. pp. 231.
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