Delayed granuloma formation in a patient with vanishing bile duct syndrome 7 years post-liver transplantation

Frank A. Anania, Charles D. Howell, Jacqueline Laurin, Cinthia I. Drachenberg

Research output: Contribution to journalArticle


A patient was found to have numerous granulomata 7 years after orthotopic liver transplantation for primary sclerosing cholangitis (PSC) on a recent liver biopsy specimen. This histopathologic finding prompted a review of the literature to determine the commonality of this feature in the absence of the usual causes of granulomatous liver disease, none of which were found to be the cause of this patient's liver histopathologic state. The presence of posttransplantation granulomata is rare, and although previously reported to occur shortly after liver transplantation, this finding has not been reported previously with either PSC or vanishing bile duct syndrome. We are not aware of another case of granulomata associated with recurrent PSC or vanishing bile duct syndrome 7 years after liver transplantation.

Original languageEnglish (US)
Pages (from-to)999-1001
Number of pages3
JournalLiver Transplantation
Issue number11
Publication statusPublished - 2001
Externally publishedYes


ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this