Delayed anaphylactoid reaction in a worker exposed to chromium

David R. Moller, Stuart M. Brooks, David I. Bernstein, Kelly Cassedy, Mary Enrione, I. Leonard Bernstein

Research output: Contribution to journalArticlepeer-review


A 29-year-old male welder reported systemic reactions after exposure to chromium. Inhalation challenge testing to 29 μg/m3 of sodium chromate aerosol resulted in late appearing systemic urticaria, angioedema, and severe bronchospasm that occurred at the same time as a threefold rise in plasma histamine. A direct leukocyte inhibitory factor test to 5.5 × 10-6mol/L Na2CrO4 was positive. Although the mechanism of this reaction is unknown, the positive leukocyte inhibitory factor and the general acceptance of hexavalent chromium as a contact skin sensitizer suggest that cell-mediated mechanisms could be involved.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalThe Journal of allergy and clinical immunology
Issue number3
StatePublished - Mar 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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