Degradable polymers for gene delivery

Joel Sunshine; Nupura Bhise; Jordan J. Green

doi:10.1109/IEMBS.2009.5334767

Degradable polymers for gene delivery

Joel Sunshine, Nupura Bhise, Jordan J. Green

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.

Original language	English (US)
Title of host publication	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Engineering the Future of Biomedicine, EMBC 2009
Publisher	IEEE Computer Society
Pages	2412-2415
Number of pages	4
ISBN (Print)	9781424432967
DOIs	https://doi.org/10.1109/IEMBS.2009.5334767
State	Published - 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

Publication series

Name	Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Country/Territory	United States
City	Minneapolis, MN
Period	9/2/09 → 9/6/09

ASJC Scopus subject areas

Cell Biology
Developmental Biology
Biomedical Engineering
General Medicine

Access to Document

10.1109/IEMBS.2009.5334767

Cite this

Sunshine, J., Bhise, N., & Green, J. J. (2009). Degradable polymers for gene delivery. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 2412-2415). Article 5334767 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334767

Degradable polymers for gene delivery. / Sunshine, Joel; Bhise, Nupura; Green, Jordan J.
Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 2412-2415 5334767 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sunshine, J, Bhise, N & Green, JJ 2009, Degradable polymers for gene delivery. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5334767, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, IEEE Computer Society, pp. 2412-2415, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334767

Sunshine J, Bhise N, Green JJ. Degradable polymers for gene delivery. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 2412-2415. 5334767. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). doi: 10.1109/IEMBS.2009.5334767

Sunshine, Joel ; Bhise, Nupura ; Green, Jordan J. / Degradable polymers for gene delivery. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 2412-2415 (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

@inproceedings{0889d0d0693f42829a669a38930d7a41,

title = "Degradable polymers for gene delivery",

abstract = "Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.",

author = "Joel Sunshine and Nupura Bhise and Green, {Jordan J.}",

year = "2009",

doi = "10.1109/IEMBS.2009.5334767",

language = "English (US)",

isbn = "9781424432967",

series = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009",

publisher = "IEEE Computer Society",

pages = "2412--2415",

booktitle = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society",

note = "31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 ; Conference date: 02-09-2009 Through 06-09-2009",

}

TY - GEN

T1 - Degradable polymers for gene delivery

AU - Sunshine, Joel

AU - Bhise, Nupura

AU - Green, Jordan J.

PY - 2009

Y1 - 2009

N2 - Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.

AB - Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.

UR - http://www.scopus.com/inward/record.url?scp=77951004556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951004556&partnerID=8YFLogxK

U2 - 10.1109/IEMBS.2009.5334767

DO - 10.1109/IEMBS.2009.5334767

M3 - Conference contribution

C2 - 19964958

AN - SCOPUS:77951004556

SN - 9781424432967

T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

SP - 2412

EP - 2415

BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society

PB - IEEE Computer Society

T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Y2 - 2 September 2009 through 6 September 2009

ER -

Degradable polymers for gene delivery

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this