TY - JOUR
T1 - Definitive chemoradiotherapy for squamous head and neck cancer
T2 - Cisplatin versus carboplatin? A meta-analysis
AU - Aguiar, Pedro Nazareth
AU - Tadokoro, Hakaru
AU - Da Silva, Gislaine Fernandes
AU - Landgraf, Mayndra Mychelle
AU - Noia Barreto, Carmelia Maria
AU - Filardi, Bruno Andraus
AU - Lopes, Gilberto De Lima
AU - Oliveira, Pedro
AU - De Mello, Ramon Andrade
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Aim: Concomitant chemoradiotherapy (with cisplatin or carboplatin) is an option of definitive treatment for squamous head and neck cancer. We aimed to perform a meta-analysis comparing those two platinum agents. Materials & methods: We carried out a systematic search on English literature between 1990 and 17 April 2015 according to the Cochrane review guidelines. Results: Five of 60 studies fulfilled inclusion criteria with 491 patients. There was no difference in response rate. Cisplatin tends to be more active systemically than carboplatin, without statistically significance; 5-year survival rate: 30 and 27%, respectively (p = 0.33). Conclusion: Despite the trend to improved outcomes in using cisplatin, carboplatin is also active and can be a reasonable option to treat patients.
AB - Aim: Concomitant chemoradiotherapy (with cisplatin or carboplatin) is an option of definitive treatment for squamous head and neck cancer. We aimed to perform a meta-analysis comparing those two platinum agents. Materials & methods: We carried out a systematic search on English literature between 1990 and 17 April 2015 according to the Cochrane review guidelines. Results: Five of 60 studies fulfilled inclusion criteria with 491 patients. There was no difference in response rate. Cisplatin tends to be more active systemically than carboplatin, without statistically significance; 5-year survival rate: 30 and 27%, respectively (p = 0.33). Conclusion: Despite the trend to improved outcomes in using cisplatin, carboplatin is also active and can be a reasonable option to treat patients.
KW - carboplatin
KW - chemoradiotherapy
KW - chemotherapy
KW - cisplatin
KW - head and neck
UR - http://www.scopus.com/inward/record.url?scp=84995451004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995451004&partnerID=8YFLogxK
U2 - 10.2217/fon-2016-0068
DO - 10.2217/fon-2016-0068
M3 - Article
C2 - 27549331
AN - SCOPUS:84995451004
VL - 12
SP - 2755
EP - 2764
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 23
ER -