Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review

Shahla M. Jilani, Chloe J. Jordan, Lauren M. Jansson, Jonathan M. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

Neonatal abstinence syndrome (NAS) results from discontinuation of in utero exposures to opioids/substances. The rising incidence of NAS has prompted an increased need for accurate research and public health data. To examine how NAS has been defined in clinical studies of opioid-exposed mothers and infants, a review process was developed based on the RAND/UCLA Appropriateness Method, yielding 888 abstracts. Per inclusion criteria, 57 abstracts underwent full-text review. To define NAS, studies cited using modified versions of the Finnegan NAS scoring tool (n = 21; 37%), ICD-9/10 coding (n = 17; 30%), original Finnegan tool (n = 16; 28%), Eat Sleep Console (n = 3; 5%), and Lipsitz (n = 3; 5%) tools, (3 cited 2+ tools). Most studies utilized subjective NAS scoring/assessment algorithms and neonatal coding as key elements defining NAS. While most cited opioid exposure as integral to their inclusion criteria, 26% did not. These approaches highlight the need for a more refined and standardized definition of NAS.

Original languageEnglish (US)
Pages (from-to)1364-1371
Number of pages8
JournalJournal of Perinatology
Volume41
Issue number6
DOIs
StatePublished - Jun 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint

Dive into the research topics of 'Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review'. Together they form a unique fingerprint.

Cite this