Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)z

Andrew S. Levey, Kai Uwe Eckardt, Yusuke Tsukamoto, Adeera Levin, Josef Coresh, Jerome Rossert, Dick De Zeeuw, Thomas H. Hostetter, Norbert Lameire, Garabed Eknoyan, Kerry Willis

Research output: Contribution to journalArticle

Abstract

Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. A simple definition and classification of kidney disease is necessary for international development and implementation of clinical practice guidelines. Kidney Disease: Improving Global Outcomes (KDIGO) conducted a survey and sponsored a controversies conference to (1) provide a clear understanding to both the nephrology and nonnephrology communities of the evidence base for the definition and classification recommended by Kidney Disease Quality Outcome Initiative (K/DOQI), (2) develop global consensus for the adoption of a simple definition and classification system, and (3) identify a collaborative research agenda and plan that would improve the evidence base and facilitate implementation of the definition and classification of CKD. The K/DOQI definition and classification were accepted, with clarifications. CKD is defined as kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m 2 for 3 months or more, irrespective of cause. Kidney damage in many kidney diseases can be ascertained by the presence of albuminuria, defined as albumin-to-creatinine ratio >30 mg/g in two of three spot urine specimens. GFR can be estimated from calibrated serum creatinine and estimating equations, such as the Modification of Diet in Renal Disease (MDRD) Study equation or the Cockcroft-Gault formula. Kidney disease severity is classified into five stages according to the level of GFR. Kidney disease treatment by dialysis and transplantation should be noted. Simple, uniform classifications of CKD by cause and by risks for kidney disease progression and CVD should be developed.

Original languageEnglish (US)
Pages (from-to)2089-2100
Number of pages12
JournalKidney international
Volume67
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Keywords

  • Albuminuria
  • Chronic kidney disease
  • Glomerular filtration rate
  • KDIGO
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology

Cite this

Levey, A. S., Eckardt, K. U., Tsukamoto, Y., Levin, A., Coresh, J., Rossert, J., De Zeeuw, D., Hostetter, T. H., Lameire, N., Eknoyan, G., & Willis, K. (2005). Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)z. Kidney international, 67(6), 2089-2100. https://doi.org/10.1111/j.1523-1755.2005.00365.x