@article{681427c662bc4b40866354b90920da2e,
title = "Defining Treatment Outcomes in Pediatric Obsessive-Compulsive Disorder Using a Self-Report Scale",
abstract = "This study examined benchmarks of treatment response and clinical remission on the Obsessive Compulsive Inventory–Child Version (OCI-CV) for youth with obsessive-compulsive disorder (OCD). Participants were 91 youth who enrolled in a randomized controlled trial that examined the benefit of augmenting cognitive behavior therapy (CBT) with either d-cycloserine or placebo. Youth completed the OCI-CV at baseline, Week 4 (prior to initiating exposure therapy), and posttreatment. Receiver operator curve (ROC) analyses examined optimal benchmarks for treatment response and clinical remission as identified by independent evaluators at the posttreatment assessment using the Clinical Global Impression (CGI) scales of Improvement (CGI-Improvement), Severity (CGI-Severity), and Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). Optimal benchmarks for treatment response were a 20%–25% reduction in the OCI-CV total score. Meanwhile, optimal benchmarks for remission were a 55%–65% reduction in the OCI-CV total score and a posttreatment total score ≤ 6-8. OCI-CV benchmarks exhibited moderate agreement with the CY-BOCS for treatment response and clinical remission. Meanwhile, fair agreement was observed for response and remission with CGI scales. A lower pretreatment OCI-CV total score was associated with less agreement between classification approaches. Findings provide benchmarks for classifying treatment response and clinical remission in an efficient manner. Given the moderate agreement between the CY-BOCS and OCI-CV benchmarks, the OCI-CV may serve as a useful alternative when clinician-rated scales cannot be administered due to limited resources (e.g., time, training). Thus, evidence-based measurement can be incorporated to monitor therapeutic response and remission in clinical practice.",
keywords = "adolescents, children, cognitive-behavior therapy, evidence-based assessment, obsessive-compulsive disorder",
author = "McGuire, {Joseph F.} and Geller, {Daniel A.} and Murphy, {Tanya K.} and Small, {Brent J.} and Arianna Unger and Sabine Wilhelm and Storch, {Eric A.}",
note = "Funding Information: Dr. McGuire receives research support from the Tourette Association of America and the American Academy of Neurology. He receives consulting fees from Brackett, and also receives book royalties from Elsevier. Funding Information: Dr. Wilhelm reports receiving research support in the form of free medication and matching placebo from Forest Laboratories for a National Institute of Mental Health–funded clinical trial; reported being a presenter for the Massachusetts General Hospital Psychiatry Academy in educational programs supported through independent medical education grants from pharmaceutical companies; reported receiving royalties from Elsevier Publications, Guilford Publications, and New Harbinger Publications; reported receiving salary support from Novartis; reported receiving speaking honoraria from various academic institutions and foundations, including the International OCD Foundation and Tourette Association of America; and reported receiving payment from the Association for Behavioral and Cognitive Therapies for her role as associate editor for the Behavior Therapy journal, as well as from John Wiley & Sons Inc for her role as associate editor for the Depression and Anxiety journal. Funding Information: We acknowledge the contributions of Adam Lewin, Ph.D., Jane Mutch, Ph.D., Allison Kennel, ARNP, Nicole McBride, BS; Noah Berman, Ph.D., Alyssa Faro Kesley Ramsay, Ashley Brown, Andrew Mittelman, Abigail Stark, Allison Cooperman, and Angelina Gomez. This work was supported in part by grants 1R01MH093381 (Dr. Storch) and 5R01MH093402 (Dr. Geller) from the National Institute of Mental Health. The funding organization was not involved in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, and approval of the manuscript; or decision to submit the manuscript for publication. Funding Information: ?, We acknowledge the contributions of Adam Lewin, Ph.D., Jane Mutch, Ph.D., Allison Kennel, ARNP, Nicole McBride, BS; Noah Berman, Ph.D., Alyssa Faro Kesley Ramsay, Ashley Brown, Andrew Mittelman, Abigail Stark, Allison Cooperman, and Angelina Gomez. This work was supported in part by grants 1R01MH093381 (Dr. Storch) and 5R01MH093402 (Dr. Geller) from the National Institute of Mental Health. The funding organization was not involved in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, and approval of the manuscript; or decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2018",
year = "2019",
month = mar,
doi = "10.1016/j.beth.2018.06.003",
language = "English (US)",
volume = "50",
pages = "314--324",
journal = "Behavior Therapy",
issn = "0005-7894",
publisher = "Elsevier Inc.",
number = "2",
}