Defining the success of cardiac gene therapy: How can nuclear imaging contribute?

Norbert Avril, Frank M. Bengel

Research output: Contribution to journalArticle

Abstract

Gene therapy is a promising modality for the treatment of various cardiovascular diseases such as ischaemia, heart failure, restenosis after revascularisation, hypertension and hyperlipidaemia. An increasing number of approaches are moving from experimental and preclinical validation to clinical application, and several multi-centre trials are currently underway. Despite the rapid progress in cardiac gene therapy, many basic tools and principles remain under development. Questions with regard to the optimal method for gene delivery in a given situation remain open, as do questions concerning therapeutic efficacy and the time course and magnitude of gene expression in target and remote areas. Nuclear imaging provides valuable tools to address these open issues non-invasively. Functional effects of molecular therapy at the tissue level can be identified using tracers of blood flow, metabolism, innervation or cell death. The use of reporter genes and radio-labelled reporter probes allows for non-invasive assessment of location, magnitude and persistence of transgene expression in the heart and the whole body. Co-expression of a reporter gene will allow for indirect imaging of the expression of a therapeutic gene of choice, and linkage of measures of transgene expression to downstream functional effects will enhance the understanding of basic mechanisms of cardiac gene therapy. Hence, nuclear imaging offers great potential to facilitate and refine the determination of therapeutic effects in preclinical and clinical cardiovascular gene therapy.

Original languageEnglish (US)
Pages (from-to)757-771
Number of pages15
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume30
Issue number5
StatePublished - May 1 2003
Externally publishedYes

Keywords

  • Gene therapy
  • Myocardium
  • Nuclear cardiology
  • Positron emission tomography
  • Reporter gene

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Defining the success of cardiac gene therapy: How can nuclear imaging contribute?'. Together they form a unique fingerprint.

  • Cite this