Defining the cut point between low-grade and high-grade ovarian serous carcinomas: A clinicopathologic and molecular genetic analysis

Ayse Ayhan, Robert J. Kurman, Anna Yemelyanova, Russell Vang, Sanjay Logani, Jeffrey D. Seidman, Ie Ming Shih

Research output: Contribution to journalArticlepeer-review

Abstract

A 2-tier grading system based on nuclear grade divides ovarian serous carcinomas into low (nuclear grade 1) and high grade (nuclear grade 3). In most instances the separation is straightforward but at times, the morphologic distinction between them can be difficult. We studied 11 ovarian serous carcinomas with features that were "intermediate" (nuclear grade 2) between low and high grade. All the cases were high staged and had a poor clinical outcome. None of the tumors showed mutations in KRAS, BRAF, and ERBB2 genes that characterize most low-grade serous carcinomas. In contrast, 10 (90.9%) of 11 cases contained nonsynonymous TP53 mutations characteristic of high-grade serous carcinomas. In summary, the molecular genetic profile and behavior of serous carcinomas with grade 2 nuclei are virtually the same as those of serous carcinomas with grade 3 nuclei, supporting the use of the 2-tier grading system for classifying ovarian serous carcinomas.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume33
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • 2-tier grading system
  • Grade
  • Ovarian cancer
  • Serous carcinoma
  • TP53

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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