Defining the clinical course of multiple sclerosis: The 2013 revisions

Fred D. Lublin; Stephen C. Reingold; Jeffrey A. Cohen; Gary R. Cutter; Per Soelberg Sørensen; Alan J. Thompson; Jerry S. Wolinsky; Laura J. Balcer; Brenda Banwell; Frederik Barkhof; Bruce Bebo; Peter A. Calabresi; Michel Clanet; Giancarlo Comi; Robert J. Fox; Mark S. Freedman; Andrew D. Goodman; Matilde Inglese; Ludwig Kappos; Bernd C. Kieseier; John A. Lincoln; Catherine Lubetzki; Aaron E. Miller; Xavier Montalban; Paul W. O'Connor; John Petkau; Carlo Pozzilli; Richard A. Rudick; Maria Pia Sormani; Olaf Stüve; Emmanuelle Waubant; Chris H. Polman

doi:10.1212/WNL.0000000000000560

Defining the clinical course of multiple sclerosis: The 2013 revisions

Fred D. Lublin, Stephen C. Reingold, Jeffrey A. Cohen, Gary R. Cutter, Per Soelberg Sørensen, Alan J. Thompson, Jerry S. Wolinsky, Laura J. Balcer, Brenda Banwell, Frederik Barkhof, Bruce Bebo, Peter A. Calabresi, Michel Clanet, Giancarlo Comi, Robert J. Fox, Mark S. Freedman, Andrew D. Goodman, Matilde Inglese, Ludwig Kappos, Bernd C. KieseierJohn A. Lincoln, Catherine Lubetzki, Aaron E. Miller, Xavier Montalban, Paul W. O'Connor, John Petkau, Carlo Pozzilli, Richard A. Rudick, Maria Pia Sormani, Olaf Stüve, Emmanuelle Waubant, Chris H. Polman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1309 Scopus citations

Abstract

Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.

Original language	English (US)
Pages (from-to)	278-286
Number of pages	9
Journal	Neurology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1212/WNL.0000000000000560
State	Published - Jul 15 2014

ASJC Scopus subject areas

Clinical Neurology

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Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sørensen, P. S., Thompson, A. J., Wolinsky, J. S., Balcer, L. J., Banwell, B., Barkhof, F., Bebo, B., Calabresi, P. A., Clanet, M., Comi, G., Fox, R. J., Freedman, M. S., Goodman, A. D., Inglese, M., Kappos, L., ... Polman, C. H. (2014). Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology, 83(3), 278-286. https://doi.org/10.1212/WNL.0000000000000560

Lublin, FD, Reingold, SC, Cohen, JA, Cutter, GR, Sørensen, PS, Thompson, AJ, Wolinsky, JS, Balcer, LJ, Banwell, B, Barkhof, F, Bebo, B, Calabresi, PA, Clanet, M, Comi, G, Fox, RJ, Freedman, MS, Goodman, AD, Inglese, M, Kappos, L, Kieseier, BC, Lincoln, JA, Lubetzki, C, Miller, AE, Montalban, X, O'Connor, PW, Petkau, J, Pozzilli, C, Rudick, RA, Sormani, MP, Stüve, O, Waubant, E & Polman, CH 2014, 'Defining the clinical course of multiple sclerosis: The 2013 revisions', Neurology, vol. 83, no. 3, pp. 278-286. https://doi.org/10.1212/WNL.0000000000000560

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abstract = "Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.",

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AU - Sørensen, Per Soelberg

AU - Thompson, Alan J.

AU - Wolinsky, Jerry S.

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AU - Bebo, Bruce

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AU - Fox, Robert J.

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AU - Goodman, Andrew D.

AU - Inglese, Matilde

AU - Kappos, Ludwig

AU - Kieseier, Bernd C.

AU - Lincoln, John A.

AU - Lubetzki, Catherine

AU - Miller, Aaron E.

AU - Montalban, Xavier

AU - O'Connor, Paul W.

AU - Petkau, John

AU - Pozzilli, Carlo

AU - Rudick, Richard A.

AU - Sormani, Maria Pia

AU - Stüve, Olaf

AU - Waubant, Emmanuelle

AU - Polman, Chris H.

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Defining the clinical course of multiple sclerosis: The 2013 revisions

Abstract

ASJC Scopus subject areas

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