Defining optimal head-tilt position of resuscitation in neonates and young infants using magnetic resonance imaging data

Utpal S. Bhalala, Malvi Hemani, Meehir Shah, Barbara Kim, Brian Gu, Angelo Cruz, Priya Arunachalam, Elli Tian, Christine Yu, Joshua Punnoose, Steven Chen, Christopher Petrillo, Alisa Brown, Karina Munoz, Grant Kitchen, Taylor Lam, Thangamadhan Bosemani, Thierry A G M Huisman, Robert Allen, Soumyadipta Acharya

Research output: Contribution to journalArticle

Abstract

Head-tilt maneuver assists with achieving airway patency during resuscitation. However, the relationship between angle of head-tilt and airway patency has not been defined. Our objective was to define an optimal head-tilt position for airway patency in neonates (age: 0-28 days) and young infants (age: 29 days-4 months). We performed a retrospective study of head and neck magnetic resonance imaging (MRI) of neonates and infants to define the angle of head-tilt for airway patency. We excluded those with an artificial airway or an airway malformation. We defined head-tilt angle a priori as the angle between occipito- ophisthion line and ophisthion-C7 spinous process line on the sagittal MR images. We evaluated medical records for Hypoxic Ischemic Encephalopathy (HIE) and exposure to sedation during MRI.We analyzed MRI of head and neck regions of 63 children (53 neonates and 10 young infants). Of these 63 children, 17 had evidence of airway obstruction and 46 had a patent airway on MRI. Also, 16/63 had underlying HIE and 47/63 newborn infants had exposure to sedative medications during MRI. In spontaneously breathing and neurologically depressed newborn infants, the head-tilt angle (median ± SD) associated with patent airway (125.3° ± 11.9°) was significantly different from that of blocked airway (108.2° ± 17.1°) (Mann Whitney U-test, p = 0.0045). The logistic regression analysis showed that the proportion of patent airways progressively increased with an increasing head-tilt angle, with > 95% probability of a patent airway at head-tilt angle 144-150°.

Original languageEnglish (US)
Article numbere0151789
JournalPLoS One
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

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Resuscitation
Magnetic resonance
magnetic resonance imaging
neonates
Head
Magnetic Resonance Imaging
Newborn Infant
Imaging techniques
patents
Brain Hypoxia-Ischemia
encephalopathy
neck
Neck
sedatives
sedation
Airway Obstruction
Nonparametric Statistics
Hypnotics and Sedatives
retrospective studies
drug therapy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Defining optimal head-tilt position of resuscitation in neonates and young infants using magnetic resonance imaging data. / Bhalala, Utpal S.; Hemani, Malvi; Shah, Meehir; Kim, Barbara; Gu, Brian; Cruz, Angelo; Arunachalam, Priya; Tian, Elli; Yu, Christine; Punnoose, Joshua; Chen, Steven; Petrillo, Christopher; Brown, Alisa; Munoz, Karina; Kitchen, Grant; Lam, Taylor; Bosemani, Thangamadhan; Huisman, Thierry A G M; Allen, Robert; Acharya, Soumyadipta.

In: PLoS One, Vol. 11, No. 3, e0151789, 01.03.2016.

Research output: Contribution to journalArticle

Bhalala, US, Hemani, M, Shah, M, Kim, B, Gu, B, Cruz, A, Arunachalam, P, Tian, E, Yu, C, Punnoose, J, Chen, S, Petrillo, C, Brown, A, Munoz, K, Kitchen, G, Lam, T, Bosemani, T, Huisman, TAGM, Allen, R & Acharya, S 2016, 'Defining optimal head-tilt position of resuscitation in neonates and young infants using magnetic resonance imaging data', PLoS One, vol. 11, no. 3, e0151789. https://doi.org/10.1371/journal.pone.0151789
Bhalala, Utpal S. ; Hemani, Malvi ; Shah, Meehir ; Kim, Barbara ; Gu, Brian ; Cruz, Angelo ; Arunachalam, Priya ; Tian, Elli ; Yu, Christine ; Punnoose, Joshua ; Chen, Steven ; Petrillo, Christopher ; Brown, Alisa ; Munoz, Karina ; Kitchen, Grant ; Lam, Taylor ; Bosemani, Thangamadhan ; Huisman, Thierry A G M ; Allen, Robert ; Acharya, Soumyadipta. / Defining optimal head-tilt position of resuscitation in neonates and young infants using magnetic resonance imaging data. In: PLoS One. 2016 ; Vol. 11, No. 3.
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