Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS

Alan Winston; Andrea Antinori; Paola Cinque; Howard S. Fox; Magnus Gisslen; Timothy J. Henrich; Scott Letendre; Deborah Persaud; Richard W. Price; Serena Spudich

doi:10.1097/QAD.0000000000002252

Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS

Alan Winston, Andrea Antinori, Paola Cinque, Howard S. Fox, Magnus Gisslen, Timothy J. Henrich, Scott Letendre, Deborah Persaud, Richard W. Price, Serena Spudich

School of Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.

Original language	English (US)
Pages (from-to)	S107-S111
Journal	AIDS
Volume	33
DOIs	https://doi.org/10.1097/QAD.0000000000002252
State	Published - Dec 1 2019

Keywords

HIV RNA
central nervous system
cerebrospinal fluid
cerebrospinal fluid escape

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000002252

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title = "Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS",

abstract = "Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.",

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T2 - Editorial review AIDS

AU - Winston, Alan

AU - Antinori, Andrea

AU - Cinque, Paola

AU - Fox, Howard S.

AU - Gisslen, Magnus

AU - Henrich, Timothy J.

AU - Letendre, Scott

AU - Persaud, Deborah

AU - Price, Richard W.

AU - Spudich, Serena

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.

AB - Suppression of plasma HIV RNA is most often attainable with effective antiretroviral therapy. Despite this, in some individuals, detection of HIV RNA remains evident in the cerebrospinal fluid (CSF) which is generally termed CSF HIV RNA escape. Defining CSF HIV RNA escape from a virological point of view, a symptomatology point of view and its management has many challenges with several different definitions being utilized. In this editorial, we outline proposed consensus definitions of CSF HIV RNA escape with consideration of virological, symptomatology and management aspects of this condition.

KW - HIV RNA

KW - central nervous system

KW - cerebrospinal fluid

KW - cerebrospinal fluid escape

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VL - 33

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JO - AIDS

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Defining cerebrospinal fluid HIV RNA escape: Editorial review AIDS

Abstract

Keywords

ASJC Scopus subject areas

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