Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor

Hans S. Crombag, Alexander W. Johnson, Anne M. Zimmer, Andreas Zimmer, Peter C. Holland

Research output: Contribution to journalArticlepeer-review

Abstract

Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.

Original languageEnglish (US)
Pages (from-to)807-811
Number of pages5
JournalLearning and Memory
Volume17
Issue number1
DOIs
StatePublished - Jan 2010

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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