Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study

Joshua R. Lupton, Kamil F. Faridi, Seth Martin, Sristi Sharma, Krishnaji Kulkarni, Steven Jones, Erin Donnelly Michos

Research output: Contribution to journalArticle

Abstract

Background Cross-sectional studies have found an association between deficiencies in serum vitamin D, as measured by 25-hydroxyvitamin D (25[OH]D), and an atherogenic lipid profile. These studies have focused on a limited panel of lipid values including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Objective Our study examines the relationship between serum 25(OH)D and an extended lipid panel (Vertical Auto Profile) while controlling for age, gender, glycemic status, and kidney function. Methods We used the Very Large Database of Lipids, which includes US adults clinically referred for analysis of their lipid profile from 2009 to 2011. Our study focused on 20,360 subjects who had data for lipids, 25(OH)D, age, gender, hemoglobin A1c, insulin, creatinine, and blood urea nitrogen. Subjects were split into groups based on serum 25(OH)D: deficient (

Original languageEnglish (US)
Pages (from-to)72-81e1
JournalJournal of Clinical Lipidology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Databases
Lipids
Serum
Blood Urea Nitrogen
Vitamin D
LDL Cholesterol
HDL Cholesterol
25-hydroxyvitamin D
Creatinine
Hemoglobins
Cross-Sectional Studies
Insulin
Kidney

Keywords

  • 25(OH)D
  • Glycemic status
  • Kidney function
  • Lipid
  • Lipoprotein
  • Vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile : The Very Large Database of Lipids (VLDL-3) study. / Lupton, Joshua R.; Faridi, Kamil F.; Martin, Seth; Sharma, Sristi; Kulkarni, Krishnaji; Jones, Steven; Michos, Erin Donnelly.

In: Journal of Clinical Lipidology, Vol. 10, No. 1, 01.01.2016, p. 72-81e1.

Research output: Contribution to journalArticle

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