TY - JOUR
T1 - Deficient Red-Cell Spectrin in Severe, Recessively Inherited Spherocytosis
AU - Agre, Peter
AU - Orringer, Eugene P.
AU - Bennett, Vann
PY - 1982/5/13
Y1 - 1982/5/13
N2 - RED-CELL-membrane architecture has been extensively studied in recent years.1,2 When the cells are hypotonically lysed and washed free of hemoglobin, the resulting membrane ghosts consist of the lipid bilayer and associated proteins. When ghosts are extracted with non-ionic detergents, lipid and integral membrane proteins are removed, leaving a cytoskeleton3 that is thought to be responsible for the shape, strength, and reversible deformability of the cell. The cytoskeleton consists of an assembly of polypeptides: spectrin (the largest and most abundant protein of the membrane), band 4.1, and actin. The cytoskeleton is attached to the membrane by the association of spectrin with.
AB - RED-CELL-membrane architecture has been extensively studied in recent years.1,2 When the cells are hypotonically lysed and washed free of hemoglobin, the resulting membrane ghosts consist of the lipid bilayer and associated proteins. When ghosts are extracted with non-ionic detergents, lipid and integral membrane proteins are removed, leaving a cytoskeleton3 that is thought to be responsible for the shape, strength, and reversible deformability of the cell. The cytoskeleton consists of an assembly of polypeptides: spectrin (the largest and most abundant protein of the membrane), band 4.1, and actin. The cytoskeleton is attached to the membrane by the association of spectrin with.
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U2 - 10.1056/NEJM198205133061906
DO - 10.1056/NEJM198205133061906
M3 - Article
C2 - 7070419
AN - SCOPUS:0020083327
SN - 0028-4793
VL - 306
SP - 1155
EP - 1161
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 19
ER -