Defibrinogenation after Intra-Amniotic Injection of Hypertonic Saline

Jerry L. Spivak, Donald B. Spangler, William R. Bell

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


In one patient generalized hemorrhage associated with hypofibrinogenemia and elevated fibrinogen-fibrin degradation products occurred two hours after the intra-amniotic injection of hypertonic saline. Serial coagulation studies were then performed on 12 patients undergoing abortion by intra-amniotic injection of 20 per cent sodium chloride, and six patients during normal labor and delivery. During normal delivery there was only a slight elevation of fibrinogen-fibrin degradation products. After injection of hypertonic saline solution, fibrinogen and platelets decreased significantly, and fibrinogen-fibrin degradation products increased.

Original languageEnglish (US)
Pages (from-to)321-323
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Aug 17 1972

ASJC Scopus subject areas

  • Medicine(all)


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