Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitus

Naoya Hattori, Oliver Schnell, Frank M. Bengel, Julian Rihl, Stephan G. Nekolla, Alexander E. Drzezga, Eberhard Standl, Markus Schwaiger

Research output: Contribution to journalArticle

Abstract

Effects of oxygen-derived free radicals are suggested to be a potential pathogenic factor for endothelial dysfunction. In this study we sought to evaluate the effect of hydroxyl radicals on the human coronary vascular bed in type I diabetes mellitus using positron emission tomography (PET). Thirteen patients with type 1 diabetes underwent PET using nitrogen-13 ammonia at rest and during sympathetic stimulation with the cold pressor test (CPT). The rest-stress study protocol was repeated twice (on different days) using pre-stress infusion of either saline as placebo or deferoxamine, an iron chelator which inhibits generation of hydroxyl radicals. At rest, global MBF was higher in diabetics than in normal controls (78.1±17.5 vs 63.2±14.9 mg 100 g-1 min-1, P-1 min-1; saline, 75±19 ml 100 g-1 min-1, P=NS) or MVR (deferoxamine, 1.0±0.5 mmHg ml-1 100 g-1 min-1; saline, 1.2±0.6 mmHg ml-1 100 g-1 min-1, P=NS). In conclusion, inhibition of hydroxyl radical formation using deferoxamine significantly improved the responses of coronary microvasculature to sympathetic stimulation. Hydroxyl radicals may play a role in the pathogenesis of flow abnormalities in type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)891-898
Number of pages8
JournalEuropean Journal Of Nuclear Medicine
Volume29
Issue number7
DOIs
StatePublished - 2002
Externally publishedYes

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Keywords

  • Endothelium
  • Free radicals
  • Positron emission tomography
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hattori, N., Schnell, O., Bengel, F. M., Rihl, J., Nekolla, S. G., Drzezga, A. E., Standl, E., & Schwaiger, M. (2002). Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitus. European Journal Of Nuclear Medicine, 29(7), 891-898. https://doi.org/10.1007/s00259-002-0799-0