Defective suppressor cell generation in juvenile onset diabetes

M. M. Lederman, J. J. Ellner, H. M. Rodman

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphocytes of juvenile onset, insulin-dependent diabetics failed to generate suppressor cell activity after preincubation with concanavalin A (Con A). The mean suppression of the autologous proliferative response to phytohemagglutinin (PHA) was 6.1 ± 7.8% (mean ± SEM) in the diabetics and 34.0 ± 4.9% in 9 age-matched healthy controls (p

Original languageEnglish (US)
Pages (from-to)2051-2055
Number of pages5
JournalJournal of Immunology
Volume127
Issue number5
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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