Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus

M. M. Frank, M. I. Hamburger, T. J. Lawley, R. P. Kimberly, P. H. Plotz

Research output: Contribution to journalArticle

Abstract

To determine whether reticuloendothelial-system immunospecific Fc-receptor function is abnormal in patients with systemic lupus erythematosus, we studied the clearance of IgG-sensitized, 51Cr-labeld erythrocytes by these splenic macrophage membrane receptors in 15 untreated patients. Fc-specific clearance rates were strikingly abnormal in 13 of 15 patients (half-times ranging from 80 to 2256 minutes, P <0.001 as compared to controls). Abnormal clearances correlated with immune-complex levels (as measured by the C1q-binding assay) and with disease activity. C1q-binding activity and anti-DNA titers also correlated with disease activity. The correlations of C3, C4, CH 50 and factor B with abnormal clearance and disease activity were weaker or nonexistent. The significant correlations among clearance, disease activity and C1q-binding activity suggest that the defect in Fc-receptor function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue deposition and damage.

Original languageEnglish (US)
Pages (from-to)518-523
Number of pages6
JournalNew England Journal of Medicine
Volume300
Issue number10
StatePublished - 1979
Externally publishedYes

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Mononuclear Phagocyte System
Fc Receptors
Systemic Lupus Erythematosus
Antigen-Antibody Complex
Complement Hemolytic Activity Assay
Immunoglobulin G
Erythrocytes
Macrophages
Membranes
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Frank, M. M., Hamburger, M. I., Lawley, T. J., Kimberly, R. P., & Plotz, P. H. (1979). Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. New England Journal of Medicine, 300(10), 518-523.

Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. / Frank, M. M.; Hamburger, M. I.; Lawley, T. J.; Kimberly, R. P.; Plotz, P. H.

In: New England Journal of Medicine, Vol. 300, No. 10, 1979, p. 518-523.

Research output: Contribution to journalArticle

Frank, MM, Hamburger, MI, Lawley, TJ, Kimberly, RP & Plotz, PH 1979, 'Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus', New England Journal of Medicine, vol. 300, no. 10, pp. 518-523.
Frank MM, Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. New England Journal of Medicine. 1979;300(10):518-523.
Frank, M. M. ; Hamburger, M. I. ; Lawley, T. J. ; Kimberly, R. P. ; Plotz, P. H. / Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. In: New England Journal of Medicine. 1979 ; Vol. 300, No. 10. pp. 518-523.
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