Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus

M. M. Frank, M. I. Hamburger, T. J. Lawley, R. P. Kimberly, P. H. Plotz

Research output: Contribution to journalArticle

Abstract

To determine whether reticuloendothelial-system immunospecific Fc-receptor function is abnormal in patients with systemic lupus erythematosus, we studied the clearance of IgG-sensitized, 51Cr-labeld erythrocytes by these splenic macrophage membrane receptors in 15 untreated patients. Fc-specific clearance rates were strikingly abnormal in 13 of 15 patients (half-times ranging from 80 to 2256 minutes, P <0.001 as compared to controls). Abnormal clearances correlated with immune-complex levels (as measured by the C1q-binding assay) and with disease activity. C1q-binding activity and anti-DNA titers also correlated with disease activity. The correlations of C3, C4, CH 50 and factor B with abnormal clearance and disease activity were weaker or nonexistent. The significant correlations among clearance, disease activity and C1q-binding activity suggest that the defect in Fc-receptor function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue deposition and damage.

Original languageEnglish (US)
Pages (from-to)518-523
Number of pages6
JournalNew England Journal of Medicine
Volume300
Issue number10
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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