Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils

Justin W.A. Garyu, Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler

Research output: Contribution to journalArticlepeer-review

Abstract

Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

Original languageEnglish (US)
Pages (from-to)1187-1190
Number of pages4
JournalInfection and immunity
Volume73
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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