Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis

Z. Toossi, M. E. Kleinhenz, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Patients with newly diagnosed, pulmonary tuberculosis had a tuberculin specific defect in IL-2 production. Mean PPD-induced IL-2 activity was 81.2% lower in patients as compared with healthy tuberculin reactors. PPD-induced expression of T cell IL-2 receptors was 5.9 times less in peripheral blood mononuclear cells of patients with tuberculosis as compared with healthy tuberculin reactors. Furthermore, purified IL-2 failed to correct PPD-induced blastogenesis in patients. Suppression by adherent cells was operative in one group of patients; adherent cell depletion increased their T cell production of IL-2 7.2-fold. A second group of patients with low IL-2 production did not have suppressor adherent cells and were clinically distinct, with more extensive disease on chest x ray. The basis for low IL-2 production in such individuals is unknown. Disordered regulation of IL-2 metabolism may be a key feature in the depressed cellular immune response of tuberculosis.

Original languageEnglish (US)
Pages (from-to)1162-1172
Number of pages11
JournalJournal of Experimental Medicine
Volume163
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Pulmonary Tuberculosis
Tuberculin
Interleukin-2
Tuberculosis
T-Lymphocytes
Interleukin-2 Receptors
Lymphocyte Activation
Cellular Immunity
Blood Cells
Thorax
X-Rays

ASJC Scopus subject areas

  • Immunology

Cite this

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. / Toossi, Z.; Kleinhenz, M. E.; Ellner, J. J.

In: Journal of Experimental Medicine, Vol. 163, No. 5, 1986, p. 1162-1172.

Research output: Contribution to journalArticle

Toossi, Z, Kleinhenz, ME & Ellner, JJ 1986, 'Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis', Journal of Experimental Medicine, vol. 163, no. 5, pp. 1162-1172.
Toossi, Z. ; Kleinhenz, M. E. ; Ellner, J. J. / Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. In: Journal of Experimental Medicine. 1986 ; Vol. 163, No. 5. pp. 1162-1172.
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