Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers

Krishna T. Patel; Michael C. Stevens; Godfrey D. Pearlson; Anderson M. Winkler; Keith A. Hawkins; Pawel Skudlarski; Lance O. Bauer

doi:10.1007/s11682-012-9187-y

Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers

Krishna T. Patel, Michael C. Stevens, Godfrey D. Pearlson, Anderson M. Winkler, Keith A. Hawkins, Pawel Skudlarski, Lance O. Bauer

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and 11 demographically matched ApoE4 carriers. Cognitive tests were also administered. All of the participants were middle-aged adults. The analysis revealed no cognitive or white matter FA differences between carriers and non-carriers. However, in DMN regions previously implicated in AD, we did detect decreased functional connectivity. Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among individuals at increased genetic risk for AD.

Original language	English (US)
Pages (from-to)	60-67
Number of pages	8
Journal	Brain Imaging and Behavior
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/s11682-012-9187-y
State	Published - Mar 2013
Externally published	Yes

Keywords

Aging
Alzheimer's disease
Apolipoprotein E (ApoE)
DTI
Default mode network
Resting state fMRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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title = "Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers",

abstract = "Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and 11 demographically matched ApoE4 carriers. Cognitive tests were also administered. All of the participants were middle-aged adults. The analysis revealed no cognitive or white matter FA differences between carriers and non-carriers. However, in DMN regions previously implicated in AD, we did detect decreased functional connectivity. Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among individuals at increased genetic risk for AD.",

keywords = "Aging, Alzheimer's disease, Apolipoprotein E (ApoE), DTI, Default mode network, Resting state fMRI",

author = "Patel, {Krishna T.} and Stevens, {Michael C.} and Pearlson, {Godfrey D.} and Winkler, {Anderson M.} and Hawkins, {Keith A.} and Pawel Skudlarski and Bauer, {Lance O.}",

note = "Funding Information: Acknowledgements This research was supported by a research grant from the Connecticut Department of Public Health (Principal Investigator—Lance Bauer, Ph.D., University of Connecticut). Additional support was provided by Public Health Service grant M01RR006192.",

year = "2013",

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doi = "10.1007/s11682-012-9187-y",

language = "English (US)",

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AU - Patel, Krishna T.

AU - Stevens, Michael C.

AU - Pearlson, Godfrey D.

AU - Winkler, Anderson M.

AU - Hawkins, Keith A.

AU - Skudlarski, Pawel

AU - Bauer, Lance O.

N1 - Funding Information: Acknowledgements This research was supported by a research grant from the Connecticut Department of Public Health (Principal Investigator—Lance Bauer, Ph.D., University of Connecticut). Additional support was provided by Public Health Service grant M01RR006192.

PY - 2013/3

Y1 - 2013/3

N2 - Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and 11 demographically matched ApoE4 carriers. Cognitive tests were also administered. All of the participants were middle-aged adults. The analysis revealed no cognitive or white matter FA differences between carriers and non-carriers. However, in DMN regions previously implicated in AD, we did detect decreased functional connectivity. Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among individuals at increased genetic risk for AD.

AB - Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and 11 demographically matched ApoE4 carriers. Cognitive tests were also administered. All of the participants were middle-aged adults. The analysis revealed no cognitive or white matter FA differences between carriers and non-carriers. However, in DMN regions previously implicated in AD, we did detect decreased functional connectivity. Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among individuals at increased genetic risk for AD.

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Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers

Abstract

Keywords

ASJC Scopus subject areas

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