Deep vein thrombosis prophylaxis after total-knee arthroplasty

Petros J. Boscainos, Peter McLardy-Smith, Riyaz H. Jinnah

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose of review: Despite the vast and ongoing research as well as the introduction of new diagnostic and treatment modalities, thromboembolic disease is still a major cause of morbidity and mortality in patients undergoing total-knee arthroplasty. This review highlights the current methods of deep-vein-thrombosis prophylaxis resulting from evidence-based clinical practice. Recent findings: There has been significant progress in the clinical research focusing on the prevention and treatment of deep vein thrombosis but there is still controversy over the ideal methods. Although the risk of venous thromboembolism after total-knee replacement appears to have decreased with modern surgical and perioperative care, modern lifestyle has also increased the risk factors for developing deep vein thrombosis after knee-replacement surgery. Furthermore, numbers of thromboembolic complications are increasing as total-knee arthroplasty becomes more accessible to larger parts of the population, especially those at the upper borders of the age spectrum. Summary: No one method of prophylaxis has been shown to be ideal and there is little doubt that more than one modality focusing on both mechanical and chemical means of prevention need to be employed.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalCurrent Opinion in Orthopaedics
Issue number1
StatePublished - Feb 2006


  • Deep vein thrombosis
  • Prevention
  • Thromboembolic disease
  • Total-knee arthroplasty

ASJC Scopus subject areas

  • Surgery


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