Deep brain stimulation for bipolar disorder—review and outlook

Sabrina M. Gippert, Christina Switala, Bettina H. Bewernick, Sarah Kayser, Alena Bräuer, Volker A. Coenen, Thomas E. Schlaepfer

Research output: Contribution to journalArticle

Abstract

Research on deep brain stimulation (DBS) for treatment-resistant psychiatric disorders has established preliminary efficacy signals for treatment-resistant depression. There are only few studies on DBS that included patients suffering from bipolar disorder. This article gives an overview of these studies concerning DBS targets, antidepressant efficacy, and the occurrence of manic/hypomanic symptoms under stimulation. First, promising results show that all patients experienced significant improvement in depressive symptomatology. In a single case, hypomanic symptoms occurred, but they could be resolved by adjusting stimulation parameters. Furthermore, this article highlights important clinical differences between unipolar and bipolar depression that have to be considered throughout the course of treatment.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCNS Spectrums
DOIs
StateAccepted/In press - Feb 10 2016

Fingerprint

Deep Brain Stimulation
Bipolar Disorder
Treatment-Resistant Depressive Disorder
Depressive Disorder
Antidepressive Agents
Psychiatry
Therapeutics
Research

Keywords

  • Bipolar disorder
  • deep brain stimulation
  • medial forebrain bundle
  • slMFB
  • treatment-resistant depression

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Gippert, S. M., Switala, C., Bewernick, B. H., Kayser, S., Bräuer, A., Coenen, V. A., & Schlaepfer, T. E. (Accepted/In press). Deep brain stimulation for bipolar disorder—review and outlook. CNS Spectrums, 1-4. https://doi.org/10.1017/S1092852915000577

Deep brain stimulation for bipolar disorder—review and outlook. / Gippert, Sabrina M.; Switala, Christina; Bewernick, Bettina H.; Kayser, Sarah; Bräuer, Alena; Coenen, Volker A.; Schlaepfer, Thomas E.

In: CNS Spectrums, 10.02.2016, p. 1-4.

Research output: Contribution to journalArticle

Gippert, SM, Switala, C, Bewernick, BH, Kayser, S, Bräuer, A, Coenen, VA & Schlaepfer, TE 2016, 'Deep brain stimulation for bipolar disorder—review and outlook', CNS Spectrums, pp. 1-4. https://doi.org/10.1017/S1092852915000577
Gippert SM, Switala C, Bewernick BH, Kayser S, Bräuer A, Coenen VA et al. Deep brain stimulation for bipolar disorder—review and outlook. CNS Spectrums. 2016 Feb 10;1-4. https://doi.org/10.1017/S1092852915000577
Gippert, Sabrina M. ; Switala, Christina ; Bewernick, Bettina H. ; Kayser, Sarah ; Bräuer, Alena ; Coenen, Volker A. ; Schlaepfer, Thomas E. / Deep brain stimulation for bipolar disorder—review and outlook. In: CNS Spectrums. 2016 ; pp. 1-4.
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