Decreased plasma lecithin:cholesterol acyltransferase activity in copper-deficient rats

P. W. Harvey, K. G.D. Allen

Research output: Contribution to journalArticle

Abstract

The effect of dietary copper deficiency on rat plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined. Three groups of rats were used: ad libitum-fed copper-deficient group (0.6 μg Cu/g diet); pair-fed control group (5.9 μg Cu/diet); and an ad libitum-fed control group (5.9 μg Cu/g diet). Copper deficiency produced a significant hypercholesterolemia (57% increase, P<0.001) in 63 days with a significant increase in plasma free cholesterol (44%, P<0.001). Despite the significant increase in plasma free cholesterol, fractional and molar LCAT activity were markedly decreased (74.2%, P<0.001 and 63.7%, P<0.005, respectively) in copper-deficient rats. The results of this study suggest that dietary copper deficiency affects LCAT activity.

Original languageEnglish (US)
Pages (from-to)1855-1858
Number of pages4
JournalJournal of Nutrition
Volume111
Issue number10
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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