The effect of dietary copper deficiency on rat plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined. Three groups of rats were used: ad libitum-fed copper-deficient group (0.6 μg Cu/g diet); pair-fed control group (5.9 μg Cu/diet); and an ad libitum-fed control group (5.9 μg Cu/g diet). Copper deficiency produced a significant hypercholesterolemia (57% increase, P<0.001) in 63 days with a significant increase in plasma free cholesterol (44%, P<0.001). Despite the significant increase in plasma free cholesterol, fractional and molar LCAT activity were markedly decreased (74.2%, P<0.001 and 63.7%, P<0.005, respectively) in copper-deficient rats. The results of this study suggest that dietary copper deficiency affects LCAT activity.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Nutrition|
|State||Published - Dec 1 1981|
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics