Abstract
The effect of dietary copper deficiency on rat plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined. Three groups of rats were used: ad libitum-fed copper-deficient group (0.6 μg Cu/g diet); pair-fed control group (5.9 μg Cu/diet); and an ad libitum-fed control group (5.9 μg Cu/g diet). Copper deficiency produced a significant hypercholesterolemia (57% increase, P<0.001) in 63 days with a significant increase in plasma free cholesterol (44%, P<0.001). Despite the significant increase in plasma free cholesterol, fractional and molar LCAT activity were markedly decreased (74.2%, P<0.001 and 63.7%, P<0.005, respectively) in copper-deficient rats. The results of this study suggest that dietary copper deficiency affects LCAT activity.
Original language | English (US) |
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Pages (from-to) | 1855-1858 |
Number of pages | 4 |
Journal | Journal of Nutrition |
Volume | 111 |
Issue number | 10 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics