Abstract
The effect of dietary copper deficiency on rat plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined. Three groups of rats were used: ad libitum-fed copper-deficient group (0.6 μg Cu/g diet); pair-fed control group (5.9 μg Cu/diet); and an ad libitum-fed control group (5.9 μg Cu/g diet). Copper deficiency produced a significant hypercholesterolemia (57% increase, P<0.001) in 63 days with a significant increase in plasma free cholesterol (44%, P<0.001). Despite the significant increase in plasma free cholesterol, fractional and molar LCAT activity were markedly decreased (74.2%, P<0.001 and 63.7%, P<0.005, respectively) in copper-deficient rats. The results of this study suggest that dietary copper deficiency affects LCAT activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1855-1858 |
| Number of pages | 4 |
| Journal | Journal of Nutrition |
| Volume | 111 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics