Decreased modulation of EEG oscillations in high-functioning autism during a motor control task

Joshua B. Ewen, Balaji M. Lakshmanan, Ajay S. Pillai, Danielle McAuliffe, Carrie Nettles, Mark Hallett, Nathan E. Crone, Stewart H. Mostofsky

Research output: Research - peer-reviewArticle

Abstract

Autism spectrum disorders (ASD) are thought to result in part from altered cortical excitatory-inhibitory balance; this pathophysiology may impact the generation of oscillations on electroencephalogram (EEG). We investigated premotor-parietal cortical physiology associated with praxis, which has strong theoretical and empirical associations with ASD symptomatology. Twenty five children with high-functioning ASD (HFA) and 33 controls performed a praxis task involving the pantomiming of tool use, while EEG was recorded. We assessed task-related modulation of signal power in alpha and beta frequency bands. Compared with controls, subjects with HFA showed 27% less left central (motor/premotor) beta (18–22.Hz) event-related desynchronization (ERD; p = 0.030), as well as 24% less left parietal alpha (7–13.Hz) ERD (p = 0.046). Within the HFA group, blunting of central ERD attenuation was associated with impairments in clinical measures of praxis imitation (r = −0.4; p = 0.04) and increased autism severity (r = 0.48; p = 0.016). The modulation of central beta activity is associated, among other things, with motor imagery, which may be necessary for imitation. Impaired imitation has been associated with core features of ASD. Altered modulation of oscillatory activity may be mechanistically involved in those aspects of motor network function that relate to the core symptoms of ASD.

LanguageEnglish (US)
Article number198
JournalFrontiers in Human Neuroscience
Volume10
Issue numberMAY2016
DOIs
StatePublished - May 6 2016

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Autistic Disorder
Electroencephalography
Autism Spectrum Disorder
Imagery (Psychotherapy)
Power (Psychology)

Keywords

  • Autism
  • Dyspraxia
  • Event-related desynchronization
  • Motor planning
  • Praxis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Decreased modulation of EEG oscillations in high-functioning autism during a motor control task. / Ewen, Joshua B.; Lakshmanan, Balaji M.; Pillai, Ajay S.; McAuliffe, Danielle; Nettles, Carrie; Hallett, Mark; Crone, Nathan E.; Mostofsky, Stewart H.

In: Frontiers in Human Neuroscience, Vol. 10, No. MAY2016, 198, 06.05.2016.

Research output: Research - peer-reviewArticle

Ewen JB, Lakshmanan BM, Pillai AS, McAuliffe D, Nettles C, Hallett M et al. Decreased modulation of EEG oscillations in high-functioning autism during a motor control task. Frontiers in Human Neuroscience. 2016 May 6;10(MAY2016). 198. Available from, DOI: 10.3389/fnhum.2016.00198
Ewen, Joshua B. ; Lakshmanan, Balaji M. ; Pillai, Ajay S. ; McAuliffe, Danielle ; Nettles, Carrie ; Hallett, Mark ; Crone, Nathan E. ; Mostofsky, Stewart H./ Decreased modulation of EEG oscillations in high-functioning autism during a motor control task. In: Frontiers in Human Neuroscience. 2016 ; Vol. 10, No. MAY2016.
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