Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection

Stacey C. LaGraize; Jasenka Borzan; Perry N. Fuchs

doi:10.1016/S0006-8993(03)03529-7

Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection

Stacey C. LaGraize, Jasenka Borzan, Perry N. Fuchs

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.

Original language	English (US)
Pages (from-to)	227-230
Number of pages	4
Journal	Brain research
Volume	990
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)03529-7
State	Published - Nov 14 2003

Keywords

Avoidance
Hyperalgesia
Nerve injury
Neuropathic pain
Neuropathy

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(03)03529-7

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title = "Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection",

abstract = "This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.",

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AU - Borzan, Jasenka

AU - Fuchs, Perry N.

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Y1 - 2003/11/14

N2 - This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.

AB - This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.

KW - Avoidance

KW - Hyperalgesia

KW - Nerve injury

KW - Neuropathic pain

KW - Neuropathy

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Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection

Abstract

Keywords

ASJC Scopus subject areas

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