Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection

Stacey C. LaGraize, Jasenka Borzan, Perry N. Fuchs

Research output: Contribution to journalArticle

Abstract

This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalBrain research
Volume990
Issue number1-2
DOIs
StatePublished - Nov 14 2003

Keywords

  • Avoidance
  • Hyperalgesia
  • Nerve injury
  • Neuropathic pain
  • Neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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