Decreased interleukin-1 and interleukin-2 production after splenectomy

Z. Spirer, R. Arav-Boger, V. Zakuth, E. Tzehoval, S. Dagan, B. Lev, A. Golander, I. Melamed

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Production of interleukin-1 and of interleukin-2 was measured in 57 splenectomized patients. 11 of them were after elective operations (aged 14-37 years, mean 24) and 46 posttraumatic (aged 20-36, mean 23) and in 20 appropriate controls. There was significant reduction of both interleukins in the splenectomized group, more evident in the elective group. The deficiency was not related to age of patient or time since splenectomy. These results support the view that a consequence of splenectomy is immunoregulatory deficit.

Original languageEnglish (US)
Pages (from-to)374-377, 426
Issue number7
StatePublished - Apr 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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